BBS7 and PDE8B

		BBS7	PDE8B
Description		Bardet-Biedl syndrome 7	phosphodiesterase 8B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Neuron Projection Ciliary Membrane	Cytosol
	Molecular Function	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Eye Development Heart Looping Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Determination Of Left/right Symmetry Brain Development Heart Development Visual Perception Intracellular Protein Localization Protein Transport Cell Projection Organization Melanosome Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Intracellular Transport Digestive Tract Morphogenesis Pigment Granule Aggregation In Cell Center Limb Development Cilium Assembly Primary Palate Development Non-motile Cilium Assembly	Behavioral Fear Response CAMP Catabolic Process Signal Transduction Visual Learning Operant Conditioning Negative Regulation Of Insulin Secretion Neuromuscular Process Controlling Balance Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Steroid Hormone Biosynthetic Process Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		BBSome-mediated cargo-targeting to cilium	G alpha (s) signalling events
Drugs			Caffeine Trapidil
Diseases		Bardet-Biedl syndrome (BBS)	Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Asthma ( 31959851) Hip circumference adjusted for BMI ( 34021172) Psoriasis ( 31376382)	Autoimmune thyroid disease ( 32581359) Caudate nucleus volume ( 21502949) Chronotype ( 30696823) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hyperthyroidism ( 30367059) Hypothyroidism ( 27182965 30367059 22493691) Medication use (thyroid preparations) ( 31015401) Serum thyroid-stimulating hormone levels ( 25436638) Sjögren's syndrome ( 28076899) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335 32769997 18514160)
Interacting Genes		4 interacting genes: FHOD1 JUN KRT18 PAX2
Entrez ID		55212	8622
HPRD ID		07399	04546
Ensembl ID		ENSG00000138686	ENSG00000113231
Uniprot IDs		Q8IWZ6	A0A2R8Y4E6 B3KN77 O95263
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Of Centrosome Localization Negative Regulation Of Programmed Cell Death Endothelial Microparticle Signal Transduction Negative Regulation Of Apoptotic Process Meiotic Mismatch Repair Single Thymine Insertion Binding MutSalpha Complex Response To Light Stimulus Leading Edge Cell Differentiation Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Centrosome Localization Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Pronephric Field Specification Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Regulation Of Metanephros Size Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Positive Regulation Of Metanephric DCT Cell Differentiation Optic Cup Morphogenesis Involved In Camera-type Eye Development Calcium Channel Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Guanine/thymine Mispair Binding Single Guanine Insertion Binding Response To Anisomycin Cellular Response To Anisomycin Microtubule Organizing Center Mitotic Checkpoint Complex Vestibulocochlear Nerve Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Metanephric Nephron Tubule Formation Metanephric Distal Convoluted Tubule Development Nephric Duct Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Ureter Maturation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Operant Conditioning Intracellular Cyclic Nucleotide Activated Cation Channel Complex Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Intracellularly CGMP-activated Cation Channel Activity Double-stranded DNA Binding Response To Radiation Release From Viral Latency Transcription Factor AP-1 Complex Response To Calcium Ion Centriolar Satellite	Pigment Granule Aggregation In Cell Center Primary Palate Development BBSome Pigment Granule Localization Establishment Of Melanosome Localization Digestive Tract Morphogenesis Melanosome Localization Melanosome Transport Pigment Granule Transport
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