ENOX1 and SMIM2

		ENOX1	SMIM2
Description		ecto-NOX disulfide-thiol exchanger 1	small integral membrane protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane	Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Disulfide Isomerase Activity NADH Dehydrogenase Activity Protein Binding Oxidoreductase Activity	Protein Binding
	Biological Process	Ultradian Rhythm Rhythmic Process
Pathways
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) End-stage coagulation ( 23381943) Major depressive disorder ( 23377640) Mercury levels ( 26025379) Parent of origin effect on receptive language ability (paternal) ( 32635940) Photic sneeze reflex ( 27182965) Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309) Response to tocilizumab in rheumatoid arthritis ( 22491018) Schizophrenia ( 33169155)	Dupuytren's disease ( 28886342) Factor VII activity ( 30642921) Schizophrenia ( 33169155) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625)
Interacting Genes		11 interacting genes: EEF1G EIF6 ENOX2 GORASP2 LNX1 NIF3L1 SDCBP SULT1E1 TRIM43 ZBTB16 ZMYND19	2 interacting genes: UBQLN1 UBQLN2
Entrez ID		55068	79024
HPRD ID		07644	14691
Ensembl ID		ENSG00000120658	ENSG00000226519
Uniprot IDs		A0A024RDT8 A0A0S2Z5N4 Q8TC92
PDB IDs
Enriched GO Terms of Interacting Partners?			Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Autophagosome Organization Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Vacuole Organization Negative Regulation Of G Protein-coupled Receptor Internalization Ultradian Rhythm Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Clathrin-dependent Endocytosis Autophagy Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Proteolysis NADH Dehydrogenase Activity Negative Regulation Of Transport Regulation Of Toll-like Receptor 3 Signaling Pathway Proteasomal Protein Catabolic Process Aggrephagy Regulation Of Cellular Response To Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Ubiquitin-dependent Protein Catabolic Process Protein Disulfide Isomerase Activity Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Transporter Activity Organelle Assembly Negative Regulation Of Receptor-mediated Endocytosis Aggresome Positive Regulation Of Protein Metabolic Process Negative Regulation Of Calcium Ion Transmembrane Transport Cytoplasmic Vesicle Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagosome Assembly
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