PHKA1 and PIGO

		PHKA1	PIGO
Description		phosphorylase kinase regulatory subunit alpha 1	phosphatidylinositol glycan anchor biosynthesis class O
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphorylase Kinase Complex Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Phosphorylase Kinase Activity Protein Binding Calmodulin Binding	Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Phosphotransferase Activity, For Other Substituted Phosphate Groups Mannose-ethanolamine Phosphotransferase Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Generation Of Precursor Metabolites And Energy Positive Regulation Of Glycogen Catabolic Process	GPI Anchor Biosynthetic Process
Pathways		Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis)	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS			Response to quetiapine in schizophrenia ( 29503163) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		2 interacting genes: PRKACA TUBGCP4	2 interacting genes: APP PIGF
Entrez ID		5255	84720
HPRD ID		02415	15134
Ensembl ID		ENSG00000067177	ENSG00000165282
Uniprot IDs		A6NMN0 P46020	Q8TEQ8
PDB IDs		8JFK 8JFL 8XY7 8XYA 8XYB
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Complex Protein-lipid Complex Assembly Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Cardiac Conduction Vascular Endothelial Cell Response To Fluid Shear Stress Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Glycolytic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cellular Response To Glucagon Stimulus Centrosome Negative Regulation Of Interleukin-2 Production Response To Laminar Fluid Shear Stress Sperm Capacitation CAMP-dependent Protein Kinase Activity Interleukin-2-mediated Signaling Pathway Calcium Channel Complex Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of ATP Metabolic Process Plasma Lipoprotein Particle Assembly Regulation Of Bicellular Tight Junction Assembly Cellular Response To Epinephrine Stimulus Multicellular Organismal-level Water Homeostasis Positive Regulation Of Cholesterol Biosynthetic Process Cell Communication By Electrical Coupling High-density Lipoprotein Particle Assembly Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Renal Water Homeostasis Response To Parathyroid Hormone Positive Regulation Of Gluconeogenesis Response To Glucagon Positive Regulation Of Protein Export From Nucleus Cellular Response To Cold Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Localization To Lipid Droplet Intracellular Potassium Ion Homeostasis Protein Kinase A Regulatory Subunit Binding Mitochondrial Protein Catabolic Process Response To Epinephrine CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Channel Activator Activity Cell Communication Involved In Cardiac Conduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Microtubule Minus-end Binding Gamma-tubulin Ring Complex Gamma-tubulin Complex Transferase Activity, Transferring Phosphorus-containing Groups Phosphotransferase Activity, For Other Substituted Phosphate Groups GPI Anchor Metabolic Process Mannose-ethanolamine Phosphotransferase Activity	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Perinuclear Region Of Cytoplasm Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Low-density Lipoprotein Particle Mediated Signaling Collagen Type XV Trimer Phosphorylase Kinase Complex Phosphorylase Kinase Activity Positive Regulation Of Glycogen Catabolic Process Ethanolaminephosphotransferase Activity Microtubule-based Process Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Regulation Of Glycogen Catabolic Process Peptidase Activator Activity Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen
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