MRPS33 and AKR1D1

		MRPS33	AKR1D1
Description		mitochondrial ribosomal protein S33	aldo-keto reductase family 1 member D1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit Ribosome Ribonucleoprotein Complex	Cytoplasm Cytosol
	Molecular Function	Structural Constituent Of Ribosome	Aldose Reductase (NADPH) Activity Steroid Binding Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Ketosteroid Monooxygenase Activity Delta4-3-oxosteroid 5beta-reductase Activity
	Biological Process	Translation Mitochondrial Translation	Alcohol Metabolic Process Lipid Metabolic Process Bile Acid Biosynthetic Process Cholesterol Catabolic Process Digestion Steroid Metabolic Process C21-steroid Hormone Metabolic Process Androgen Metabolic Process Lipid Catabolic Process Bile Acid Catabolic Process Monocarboxylic Acid Metabolic Process Hormone Metabolic Process
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs			Azelaic acid Finasteride 5beta-dihydrotestosterone 3,20-Pregnanedione
Diseases			Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756 34002096) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Waist circumference adjusted for body mass index ( 34021172)	Bipolar disorder with mood-incongruent psychosis ( 23092984) C-reactive protein levels in ischemic stroke ( 26718567) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes
Entrez ID		51650	6718
HPRD ID		17598	07263
Ensembl ID		ENSG00000090263	ENSG00000122787
Uniprot IDs		A4D1T3 Q3KRB4 Q9Y291	P51857
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2	3BUR 3BUV 3BV7 3CAQ 3CAS 3CAV 3CMF 3COT 3DOP 3G1R 3UZW 3UZX 3UZY 3UZZ
Enriched GO Terms of Interacting Partners?		Digestion Bile Acid Catabolic Process Delta4-3-oxosteroid 5beta-reductase Activity Histone H3K23ac Reader Activity Steroid Dehydrogenase Activity Regulation Of Cell-cell Adhesion Mediated By Integrin Slit Diaphragm Regulation Of Microvillus Assembly Podocyte Development Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Cholesterol Catabolic Process Ketosteroid Monooxygenase Activity Aldose Reductase (NADPH) Activity Perichromatin Fibrils Regulation Of Vitamin D Receptor Signaling Pathway Estrogen Response Element Binding Cellular Response To Estrogen Stimulus	Mitochondrial Small Ribosomal Subunit Mitochondrial Translation Ribosome Structural Constituent Of Ribosome
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