UTP18 and MBTD1

		UTP18	MBTD1
Description		UTP18 small subunit processome component	mbt domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Membrane Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome	Nucleosome Nucleus Chromosome NuA4 Histone Acetyltransferase Complex Site Of Double-strand Break
	Molecular Function	RNA Binding Protein Binding	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone H4K20me2 Reader Activity Histone H4K20me1 Reader Activity
	Biological Process	RRNA Processing Ribosomal Small Subunit Biogenesis	Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Skeletal System Development Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Menarche (age at onset) ( 27182965) Metabolite levels ( 23823483)	Bipolar disorder ( 31043756) Coronary artery disease ( 33020668) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: CSNK2A1 ERBB2 OGT	3 interacting genes: EPC1 H4C1 TULP3
Entrez ID		51096	54799
HPRD ID		10825	14369
Ensembl ID		ENSG00000011260	ENSG00000011258
Uniprot IDs		Q9Y5J1	Q05BQ5
PDB IDs		7MQ8 7MQ9 7MQA	3FEO 4C5I 6NFX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Sebum Secreting Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Response To Stress Adaptive Immune Response Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Sin3-type Complex Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Cellular Response To Mechanical Stimulus Positive Regulation Of Type II Interferon Production Negative Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Differentiation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Extrathymic T Cell Differentiation Protein Localization To Vacuole Positive Regulation Of Signal Transduction ERBB3:ERBB2 Complex Relaxation Of Skeletal Muscle Coproporphyrinogen Oxidase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Translation Transferase Activity Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body RNA Polymerase I Core Binding Protein O-acetylglucosaminyltransferase Activity Toll-like Receptor 8 Signaling Pathway Identical Protein Binding	Nucleolus Intraciliary Transport Particle A Binding Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Bronchus Morphogenesis Nucleosome Piccolo Histone Acetyltransferase Complex Pwp2p-containing Subcomplex Of 90S Preribosome Nuclear Membrane Embryonic Neurocranium Morphogenesis Neural Tube Formation Nucleoplasm Ganglion Development 9+0 Non-motile Cilium Embryonic Camera-type Eye Development Dorsal/ventral Neural Tube Patterning CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Enzyme-substrate Adaptor Activity Sperm DNA Condensation Chromatin-protein Adaptor Activity
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