CALHM6 and RSPH4A

		CALHM6	RSPH4A
Description		calcium homeostasis modulator family member 6	radial spoke head component 4A
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GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Membrane	Radial Spoke Radial Spoke Head Extracellular Region Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Cell Projection 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 2 Radial Spoke Head 3
	Molecular Function	Monoatomic Cation Channel Activity Protein Binding Voltage-gated Channel Activity
	Biological Process	Regulation Of Natural Killer Cell Cytokine Production Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport ATP Export	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Cell Projection Organization Axoneme Assembly Establishment Of Localization In Cell Cilium Assembly Cilium Movement Involved In Cell Motility Radial Spoke Assembly Maintenance Of Ciliary Planar Beating Movement Pattern
Pathways
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Childhood steroid-sensitive nephrotic syndrome ( 31263063)
Interacting Genes		3 interacting genes: CBARP HSD17B13 JAGN1
Entrez ID		441168	345895
HPRD ID		18644	18005
Ensembl ID		ENSG00000188820	ENSG00000111834
Uniprot IDs		Q5R3K3	B3KTA9 Q5TD94
PDB IDs		6YTV 6YTX	8J07
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Secretion Negative Regulation Of Secretion By Cell Steroid Dehydrogenase Activity Radial Spoke Head 2 Maintenance Of Ciliary Planar Beating Movement Pattern Radial Spoke Head 1 Radial Spoke Assembly Radial Spoke Head 3 Granulocyte Colony-stimulating Factor Signaling Pathway Radial Spoke Head Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Neutrophil Differentiation Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion-dependent Exocytosis Radial Spoke Negative Regulation Of Transport Insulin Metabolic Process Regulation Of Voltage-gated Calcium Channel Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Neutrophil Mediated Immunity	ATP Export ATP Transport Purine Nucleotide Transport Adenine Nucleotide Transport Monoatomic Cation Channel Activity Nucleotide Transport Carbohydrate Derivative Transport [heparan Sulfate]-glucosamine 3-sulfotransferase Activity Protein Sulfation Mitochondrial Protein Quality Control Organophosphate Ester Transport Voltage-gated Channel Activity Nucleobase-containing Compound Transport 3'-phosphoadenosine 5'-phosphosulfate Binding Mitochondrial Protein Catabolic Process Regulation Of Natural Killer Cell Cytokine Production Organic Anion Transport Sulfation Regulation Of Viral Entry Into Host Cell Heparan Sulfate Proteoglycan Biosynthetic Process
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