MFGE8 and TM6SF1

		MFGE8	TM6SF1
Description		milk fat globule EGF and factor V/VIII domain containing	transmembrane 6 superfamily member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Membrane Extracellular Matrix Cytoplasmic Vesicle Extracellular Exosome Extracellular Vesicle	Lysosome Lysosomal Membrane Membrane
	Molecular Function	Phosphatidylserine Binding Integrin Binding Extracellular Matrix Structural Constituent	Protein Binding
	Biological Process	Angiogenesis Cell Adhesion Single Fertilization Apoptotic Cell Clearance
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Amyloid fiber formation Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 26343387 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Major depressive disorder x sex interaction ( 34099189) Pulse pressure ( 27841878) Serum alkaline phosphatase levels ( 33547301) Squamous cell lung carcinoma ( 28604730)	Diastolic blood pressure ( 27841878) Lymphocyte count ( 32888494)
Interacting Genes		1 interacting genes: RSPH1	2 interacting genes: MFF PEX5
Entrez ID		4240	53346
HPRD ID		03789	08411
Ensembl ID		ENSG00000140545	ENSG00000136404
Uniprot IDs		A0A8Q3SIZ9 B3KTQ2 B4E396 H0YKB5 Q08431	Q6P4D7 Q9BZW5
PDB IDs
Enriched GO Terms of Interacting Partners?			Protein Import Into Peroxisome Matrix, Translocation Peroxisome Membrane Targeting Sequence Binding Peroxisome Protein Targeting Peroxisome Matrix Targeting Signal-1 Binding Mitochondrion Organization Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Establishment Of Protein Localization To Organelle Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Peroxisome Fission Protein Unfolding Protein Import Into Peroxisome Matrix Mitochondrial Fission Pexophagy Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Positive Regulation Of Mitochondrial Fission Cerebral Cortex Neuron Differentiation Acrosomal Membrane Apoptotic Cell Clearance Intracellular Protein Transmembrane Transport Cerebral Cortex Cell Migration Receptor Recycling Peroxisome Organization Regulation Of Mitochondrial Fission Protein Targeting To Mitochondrion Protein-containing Complex Positive Regulation Of Multicellular Organism Growth Very Long-chain Fatty Acid Metabolic Process Forebrain Neuron Differentiation Cytoplasmic Vesicle Telencephalon Cell Migration Forebrain Cell Migration Receptor Metabolic Process Peroxisomal Matrix Fatty Acid Beta-oxidation Protein Monoubiquitination Phosphatidylserine Binding Endoplasmic Reticulum Organization Peroxisomal Membrane Regulation Of Multicellular Organism Growth Establishment Of Protein Localization To Mitochondrion
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