FADS3 and MDN1

		FADS3	MDN1
Description		fatty acid desaturase 3	midasin AAA ATPase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process Gene Expression	Ribosomal Large Subunit Assembly Ribosome Biogenesis
Pathways
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma (adult onset) ( 31036433) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Cholesterol, total ( 24097068 19060911 20686565 25961943) Fatty acid desaturase activity (serum) ( 30453627) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 25961943 20686565 19060906 19060911 24097068) HDL cholesterol levels ( 28334899) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 20686565 25961943 19060911 24097068) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 23378610 22916037 23823483) Oleic acid (18:1n-9) levels ( 23362303) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30423114 24390342) Serum metabolite levels (CMS) ( 31636271) Sphingolipid d18:1/d18:2 ratio ( 31862735) Sphingolipid levels ( 22359512 19798445) Stearic acid (18:0) levels ( 23362303) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 25961943 24097068 20686565 19060906) Urate levels ( 31578528)	Asthma ( 31959851) Coronary artery disease ( 29212778) QRS interval (sulfonylurea treatment interaction) ( 27958378)
Interacting Genes		1 interacting genes: DHRSX	5 interacting genes: AR PTEN SUMO2 UBC USP7
Entrez ID		3995	23195
HPRD ID		07547	10069
Ensembl ID		ENSG00000221968	ENSG00000112159
Uniprot IDs		E9PKP8 Q9Y5Q0	Q9NU22
PDB IDs
Enriched GO Terms of Interacting Partners?		Dolichal Reductase (NADPH) Activity Polyprenol Dehydrogenase (NAD+) Activity Dolichyl Monophosphate Biosynthetic Process Ribosomal Large Subunit Assembly	PML Body Protein Tag Activity
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