DNAAF3 and SIGLEC14

		DNAAF3	SIGLEC14
Description		dynein axonemal assembly factor 3	sialic acid binding Ig like lectin 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Dynein Axonemal Particle	Plasma Membrane Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function		Carbohydrate Binding Sialic Acid Binding
	Biological Process	Cell Morphogenesis Spermatogenesis Determination Of Left/right Symmetry Brain Development Heart Development Determination Of Adult Lifespan Male Gonad Development Cell Projection Organization Lung Development Multicellular Organism Growth Motile Cilium Assembly Axonemal Dynein Complex Assembly Seminiferous Tubule Development Cerebrospinal Fluid Circulation	Cell Adhesion
Pathways			DAP12 interactions Neutrophil degranulation
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Plasma plasminogen levels ( 25208887)
Interacting Genes			1 interacting genes: TYROBP
Entrez ID		352909	100049587
HPRD ID		14185	19304
Ensembl ID		ENSG00000167646	ENSG00000254415
Uniprot IDs		Q8N9W5	Q08ET2
PDB IDs
Enriched GO Terms of Interacting Partners?		Sialic Acid Binding Negative Regulation Of ERBB4 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	Positive Regulation Of Osteoclast Development Microglial Cell Activation Involved In Immune Response Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Positive Regulation Of Macrophage Fusion Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of B Cell Proliferation Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Interleukin-10 Production T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Activation Involved In Immune Response Regulation Of Superoxide Anion Generation Neutrophil Activation Involved In Immune Response Microglial Cell Activation Cellular Response To Lectin Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Receptor Localization To Synapse Positive Regulation Of Superoxide Anion Generation Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Activation Regulation Of Osteoclast Development Regulation Of Superoxide Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Amyloid-beta Clearance Apoptotic Cell Clearance Neutrophil Activation Positive Regulation Of Protein Localization To Cell Surface Dynein Axonemal Particle Cerebrospinal Fluid Circulation Seminiferous Tubule Development Negative Regulation Of B Cell Activation Leukocyte Activation Involved In Inflammatory Response Determination Of Adult Lifespan Axonemal Dynein Complex Assembly Regulation Of Protein Localization To Cell Surface Regulation Of Long-term Synaptic Potentiation Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Semaphorin-plexin Signaling Pathway Negative Regulation Of Type I Interferon Production Motile Cilium Assembly Epithelial Cilium Movement Involved In Extracellular Fluid Movement Osteoclast Differentiation Extracellular Transport Cellular Defense Response Cellular Response To Amyloid-beta Response To Axon Injury Positive Regulation Of Reactive Oxygen Species Metabolic Process
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