HCN1 and C5orf34

		HCN1	C5orf34
Description		hyperpolarization activated cyclic nucleotide gated potassium channel 1	chromosome 5 open reading frame 34
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Axon Dendrite Dendrite Membrane Monoatomic Ion Channel Complex Somatodendritic Compartment Neuronal Cell Body Dendritic Shaft Axon Terminus Postsynaptic Membrane Presynaptic Active Zone Membrane Apical Dendrite HCN Channel Complex Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Intracellularly CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Voltage-gated Monoatomic Cation Channel Activity CAMP Binding Identical Protein Binding Intracellular CAMP-activated Cation Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Regulation Of Membrane Depolarization Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Neuronal Action Potential Monoatomic Ion Transmembrane Transport Cellular Response To Interferon-beta Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Maternal Behavior Apical Protein Localization Negative Regulation Of Action Potential Retinal Cone Cell Development Protein Homotetramerization Response To Calcium Ion General Adaptation Syndrome, Behavioral Process Negative Regulation Of Synaptic Transmission, Glutamatergic Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Cellular Response To CAMP Potassium Ion Transmembrane Transport Regulation Of Heart Rate By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Regulation Of SA Node Cell Action Potential Response To L-glutamate Regulation Of Membrane Hyperpolarization Positive Regulation Of Membrane Hyperpolarization Potassium Ion Import Across Plasma Membrane
Pathways		HCN channels
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Age at first birth ( 34211149 27798627) Age at first sexual intercourse ( 34211149 27089180) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Electrocardiographic traits (multivariate) ( 32602732) Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Irritable mood ( 29500382) Non-response to bupropion and depression ( 27622933) Number of sexual partners ( 30643258) P wave duration ( 28794112) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 29483656 25056061 30285260 28991256) Spatial memory ( 31596458) Squamous cell lung carcinoma ( 28604730) Survival in colon cancer ( 25866641) Survival in microsatellite instability low/stable colorectal cancer ( 25866641)	Lymphocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: HCN2 PEX5L
Entrez ID		348980	375444
HPRD ID		09099	13407
Ensembl ID		ENSG00000164588	ENSG00000172244
Uniprot IDs		O60741 Q86WJ6	Q96MH7
PDB IDs		5U6O 5U6P 6UQF 6UQG 8T4M 8T4Y 8T50 8UC7 8UC8 9BC6 9BC7
Enriched GO Terms of Interacting Partners?		Cellular Response To CGMP Ammonium Transmembrane Transport Cellular Response To Aldosterone HCN Channel Complex Intracellularly CAMP-activated Cation Channel Activity Response To CGMP Protein Import Into Peroxisome Matrix, Docking Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Cellular Response To Mineralocorticoid Stimulus Somatodendritic Compartment Membrane Depolarization During Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Response To Aldosterone CAMP Binding Membrane Depolarization During Action Potential Sodium Ion Import Across Plasma Membrane Dendrite Membrane	Negative Regulation Of Action Potential Regulation Of Membrane Hyperpolarization Intracellular CAMP-activated Cation Channel Activity Involved In Regulation Of Presynaptic Membrane Potential General Adaptation Syndrome, Behavioral Process HCN Channel Complex Regulation Of SA Node Cell Action Potential Positive Regulation Of Membrane Hyperpolarization Voltage-gated Monoatomic Cation Channel Activity Intracellularly CAMP-activated Cation Channel Activity Negative Regulation Of Synaptic Transmission, Glutamatergic Retinal Cone Cell Development Apical Dendrite Somatodendritic Compartment Voltage-gated Sodium Channel Activity Apical Protein Localization Maternal Behavior Parental Behavior Response To L-glutamate CAMP Binding Photoreceptor Cell Development Sodium Ion Import Across Plasma Membrane Sodium Channel Activity Dendrite Membrane Cellular Response To Interferon-beta Eye Photoreceptor Cell Development Regulation Of Cardiac Muscle Cell Action Potential Neuronal Action Potential Presynaptic Active Zone Membrane Phosphatidylinositol-3,4,5-trisphosphate Binding Reproductive Behavior Response To Interferon-beta Negative Regulation Of Synaptic Transmission Dendritic Shaft Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Import Across Plasma Membrane Cardiac Conduction Regulation Of Membrane Depolarization Voltage-gated Potassium Channel Activity Cellular Response To CAMP Axon Terminus Regulation Of Action Potential Protein Homotetramerization Regulation Of Synaptic Transmission, Glutamatergic Phosphatidylinositol-4,5-bisphosphate Binding Potassium Channel Activity Response To CAMP Inorganic Cation Import Across Plasma Membrane Protein Tetramerization Regulation Of Postsynaptic Membrane Potential Regulation Of Heart Rate
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