RSPH4A and CALHM6

		RSPH4A	CALHM6
Description		radial spoke head component 4A	calcium homeostasis modulator family member 6
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GO Annotations	Cellular Component	Radial Spoke Radial Spoke Head Extracellular Region Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Cell Projection 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 2 Radial Spoke Head 3	Immunological Synapse Plasma Membrane Membrane
	Molecular Function		Monoatomic Cation Channel Activity Protein Binding Voltage-gated Channel Activity
	Biological Process	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Cell Projection Organization Axoneme Assembly Establishment Of Localization In Cell Cilium Assembly Cilium Movement Involved In Cell Motility Radial Spoke Assembly Maintenance Of Ciliary Planar Beating Movement Pattern	Regulation Of Natural Killer Cell Cytokine Production Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport ATP Export
Pathways
Drugs
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS			Childhood steroid-sensitive nephrotic syndrome ( 31263063)
Interacting Genes			3 interacting genes: CBARP HSD17B13 JAGN1
Entrez ID		345895	441168
HPRD ID		18005	18644
Ensembl ID		ENSG00000111834	ENSG00000188820
Uniprot IDs		B3KTA9 Q5TD94	Q5R3K3
PDB IDs		8J07	6YTV 6YTX
Enriched GO Terms of Interacting Partners?		ATP Export ATP Transport Purine Nucleotide Transport Adenine Nucleotide Transport Monoatomic Cation Channel Activity Nucleotide Transport Carbohydrate Derivative Transport [heparan Sulfate]-glucosamine 3-sulfotransferase Activity Protein Sulfation Mitochondrial Protein Quality Control Organophosphate Ester Transport Voltage-gated Channel Activity Nucleobase-containing Compound Transport 3'-phosphoadenosine 5'-phosphosulfate Binding Mitochondrial Protein Catabolic Process Regulation Of Natural Killer Cell Cytokine Production Organic Anion Transport Sulfation Regulation Of Viral Entry Into Host Cell Heparan Sulfate Proteoglycan Biosynthetic Process	Negative Regulation Of Secretion Negative Regulation Of Secretion By Cell Steroid Dehydrogenase Activity Radial Spoke Head 2 Maintenance Of Ciliary Planar Beating Movement Pattern Radial Spoke Head 1 Radial Spoke Assembly Radial Spoke Head 3 Granulocyte Colony-stimulating Factor Signaling Pathway Radial Spoke Head Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Neutrophil Differentiation Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion-dependent Exocytosis Radial Spoke Negative Regulation Of Transport Insulin Metabolic Process Regulation Of Voltage-gated Calcium Channel Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Neutrophil Mediated Immunity
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