RSPH4A and CALHM5

		RSPH4A	CALHM5
Description		radial spoke head component 4A	calcium homeostasis modulator family member 5
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GO Annotations	Cellular Component	Radial Spoke Radial Spoke Head Extracellular Region Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Cell Projection 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 2 Radial Spoke Head 3	Plasma Membrane Membrane
	Molecular Function		Monoatomic Cation Channel Activity Protein Binding
	Biological Process	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Cell Projection Organization Axoneme Assembly Establishment Of Localization In Cell Cilium Assembly Cilium Movement Involved In Cell Motility Radial Spoke Assembly Maintenance Of Ciliary Planar Beating Movement Pattern	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport ATP Export
Pathways
Drugs
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS
Interacting Genes			1 interacting genes: CFTR
Entrez ID		345895	254228
HPRD ID		18005	12868
Ensembl ID		ENSG00000111834	ENSG00000178033
Uniprot IDs		B3KTA9 Q5TD94	Q8N5C1
PDB IDs		8J07	7D60 7D61 7D65
Enriched GO Terms of Interacting Partners?		ATP Export ATP Transport Purine Nucleotide Transport Adenine Nucleotide Transport Monoatomic Cation Channel Activity Nucleotide Transport Carbohydrate Derivative Transport [heparan Sulfate]-glucosamine 3-sulfotransferase Activity Protein Sulfation Mitochondrial Protein Quality Control Organophosphate Ester Transport Voltage-gated Channel Activity Nucleobase-containing Compound Transport 3'-phosphoadenosine 5'-phosphosulfate Binding Mitochondrial Protein Catabolic Process Regulation Of Natural Killer Cell Cytokine Production Organic Anion Transport Sulfation Regulation Of Viral Entry Into Host Cell Heparan Sulfate Proteoglycan Biosynthetic Process	Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Radial Spoke Head 2 Maintenance Of Ciliary Planar Beating Movement Pattern Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Radial Spoke Head 1 Radial Spoke Assembly Radial Spoke Head 3 Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Radial Spoke Head Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Radial Spoke Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport 9+2 Motile Cilium Regulation Of Cilium Movement Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Epithelial Cilium Movement Involved In Extracellular Fluid Movement Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Extracellular Transport Axoneme Assembly
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