ACAD9 and TMCC1

		ACAD9	TMCC1
Description		acyl-CoA dehydrogenase family member 9	transmembrane and coiled-coil domain family 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Dendrite Mitochondrial Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Endomembrane System Membrane Endoplasmic Reticulum-endosome Membrane Contact Site
	Molecular Function	Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding Medium-chain Fatty Acyl-CoA Dehydrogenase Activity	Protein Binding Identical Protein Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Fatty Acid Metabolic Process Mitochondrial Respiratory Chain Complex I Assembly Medium-chain Fatty Acid Metabolic Process	Endoplasmic Reticulum Organization Endosomal Transport Membrane Fission Endosome Membrane Tubulation Endosome Fission
Pathways		Complex I biogenesis
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Dental caries ( 23064961) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	A body shape index ( 34021172) Breast size ( 22747683) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Type 2 diabetes ( 30297969) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes			2 interacting genes: APP ZDHHC17
Entrez ID		28976	23023
HPRD ID		12412	15518
Ensembl ID		ENSG00000177646	ENSG00000172765
Uniprot IDs		Q9H845 Q9H9W4	A0A8V8TLJ9 E9PC87 O94876 Q6N039
PDB IDs		8PHE 8PHF
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Organization Pronephric Nephron Development Protein-DNA Covalent Cross-linking Activity Post-spliceosomal Complex Regulation Of DNA Recombination DNA-(abasic Site) Binding Generation Of Catalytic Spliceosome For Second Transesterification Step Endosome Fission Endosome Membrane Tubulation Endoplasmic Reticulum-endosome Membrane Contact Site Signal Sequence Binding Membrane Tubulation Sec61 Translocon Complex MRNA 3'-splice Site Recognition SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Protein-DNA Covalent Cross-linking Repair Post-mRNA Release Spliceosomal Complex Double-strand Break Repair Via Alternative Nonhomologous End Joining SRP-dependent Cotranslational Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Nephron Development Somatic Hypermutation Of Immunoglobulin Genes DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Somatic Diversification Of Immune Receptors Via Somatic Mutation Prp19 Complex U2-type Catalytic Step 1 Spliceosome Cotranslational Protein Targeting To Membrane	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Cell Recognition Cell Body Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Neuron Recognition Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Lipophagy Glutamatergic Synapse Synaptic Vesicle Recycling Via Endosome Synaptic Target Recognition Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Medium-chain Fatty Acyl-CoA Dehydrogenase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Cytoplasmic Vesicle Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Mitochondrial Membrane Negative Regulation Of Exosomal Secretion Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Long-chain Fatty Acyl-CoA Dehydrogenase Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Protein To Membrane Docking Regulation Of Endosome Organization
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