IGSF10 and MED12L

		IGSF10	MED12L
Description		immunoglobulin superfamily member 10	mediator complex subunit 12L
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Nucleus Mediator Complex
	Molecular Function		Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding
	Biological Process	Ossification Cell Differentiation Regulation Of Neuron Migration	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs		Pyridoxal phosphate
Diseases
GWAS		Refractive error ( 32231278)	Chronotype ( 30696823) Eosinophil count ( 32888494) Epstein-Barr virus EBNA-1 antibody levels ( 33204752) Heschl's gyrus morphology ( 25130324) Lymphocyte count ( 32888494) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Trunk fat mass ( 28552196) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: APP	7 interacting genes: AR CKS1B LAMTOR5 MAPK9 MSRB3 TLE5 TTC23
Entrez ID		285313	116931
HPRD ID		13732	10278
Ensembl ID		ENSG00000152580	ENSG00000144893
Uniprot IDs		Q6WRI0	A0A8I5KX78 B3KXY0 Q86YW9
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Eukaryotic Translation Initiation Factor 2 Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Cellular Response To Sterol Depletion SREBP Signaling Pathway Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Regulation Of Translation Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
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