AMT and SLMAP

		AMT	SLMAP
Description		aminomethyltransferase	sarcolemma associated protein
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Centrosome Cytoskeleton Plasma Membrane Membrane Z Disc M Band Mitochondrial Membrane Sarcolemma FAR/SIN/STRIPAK Complex
	Molecular Function	Aminomethyltransferase Activity Protein Binding Transaminase Activity Transferase Activity	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System	Muscle Contraction Hippo Signaling Negative Regulation Of Hippo Signaling Protein Localization To Plasma Membrane Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways		Glycine degradation
Drugs		Tetrahydrofolic acid NADH 5-methyltetrahydrofolic acid
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 27841878 30578418) FEV1 ( 30804560) Late-onset Alzheimer's disease ( 27770636) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Peak expiratory flow ( 30804560)
Interacting Genes		2 interacting genes: PDLIM4 VAC14	1 interacting genes: STK3
Entrez ID		275	7871
HPRD ID		01997	04079
Ensembl ID		ENSG00000145020	ENSG00000163681
Uniprot IDs		P48728	A0A590UJK3 A0A590UJS6 A0A5F9VB99 A0A994J5K5 B7Z6C7 B7Z863 B7Z964 H7C3M8 H7C5G9 Q14BN4
PDB IDs		1WSR 1WSV	6AKM 6AR0 6AR2
Enriched GO Terms of Interacting Partners?			Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Aminomethyltransferase Activity Glycine Catabolic Process Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Serine Family Amino Acid Catabolic Process Transcription Regulator Activator Activity Centrosome Separation Neural Tube Formation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Glycine Metabolic Process Transaminase Activity Hepatocyte Apoptotic Process Embryonic Epithelial Tube Formation Hippo Signaling Embryonic Hemopoiesis Positive Regulation Of Hippo Signaling Cell Differentiation Involved In Embryonic Placenta Development Protein Localization To Centrosome Serine Family Amino Acid Metabolic Process Epithelial Tube Formation Negative Regulation Of Organ Growth Regulation Of Hippo Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Cytoskeleton Epithelial Cell Apoptotic Process Organ Growth Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway JNK Cascade Positive Regulation Of Fat Cell Differentiation Protein Serine/threonine Kinase Activator Activity
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