AMT and RBM15B

		AMT	RBM15B
Description		aminomethyltransferase	RNA binding motif protein 15B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex	Nucleus Nuclear Envelope Nucleoplasm Nucleolus Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex
	Molecular Function	Aminomethyltransferase Activity Protein Binding Transaminase Activity Transferase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System	Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Methylation MRNA Processing MRNA Export From Nucleus Nucleocytoplasmic Transport RNA Splicing Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of DNA-templated Transcription
Pathways		Glycine degradation
Drugs		Tetrahydrofolic acid NADH 5-methyltetrahydrofolic acid
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Lipoprotein (a) levels ( 33730874)
Interacting Genes		2 interacting genes: PDLIM4 VAC14	11 interacting genes: ATP6V0D2 CDC23 DVL3 EGR2 ERBB2 NAV2 NXF1 RNF10 SRPK2 TNNC1 TRIM54
Entrez ID		275	29890
HPRD ID		01997	11486
Ensembl ID		ENSG00000145020	ENSG00000259956
Uniprot IDs		P48728	Q8NDT2
PDB IDs		1WSR 1WSV
Enriched GO Terms of Interacting Partners?			Motor Neuron Axon Guidance Peripheral Nervous System Development Regulation Of Nervous System Process Positive Regulation Of Myelination Rhythmic Behavior Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Rhombomere 5 Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Regulation Of Myelination Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Muscle Filament Sliding Speed Glossopharyngeal Nerve Development Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Vagus Nerve Development
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