GLDC and DNAI1

		GLDC	DNAI1
Description		glycine decarboxylase	dynein axonemal intermediate chain 1
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Glycine Cleavage Complex	Extracellular Region Cytoplasm Centrosome Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Dynein Complex Outer Dynein Arm Cell Projection Glial Cell Projection 9+2 Motile Cilium Dynein Axonemal Particle
	Molecular Function	Glycine Dehydrogenase (decarboxylating) Activity Electron Transfer Activity Oxidoreductase Activity Glycine Binding Lyase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity Pyridoxal Binding	Cytoskeletal Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Amino Acid Metabolic Process Glycine Metabolic Process Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Response To Methylamine Response To Lipoic Acid Cellular Response To Leukemia Inhibitory Factor	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Heart Development Insulin Receptor Signaling Pathway Cell Projection Organization Flagellated Sperm Motility Outer Dynein Arm Assembly
Pathways		Glycine degradation
Drugs		Pyridoxal phosphate
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)	Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Glycine levels ( 30837465 31070104) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Overall survival in osteosarcoma ( 29210060) Periodontal microbiota ( 22699663) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995)	Anti-drug antibodies in autoimmune disease (time to event) ( 33125391)
Interacting Genes		2 interacting genes: SIRT3 TLR10	2 interacting genes: PAFAH1B1 SQSTM1
Entrez ID		2731	27019
HPRD ID		01996	05080
Ensembl ID		ENSG00000178445	ENSG00000122735
Uniprot IDs		P23378	A0A087WWV9 A0A140VJI0 Q9UI46
PDB IDs		6I33 6I34 6I35	8J07
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Peptidyl-lysine Deacetylation Positive Regulation Of Oxidative Phosphorylation Toll-like Receptor 2 Binding Type I Interferon Receptor Binding Natural Killer Cell Activation Involved In Immune Response Histone Deacetylase Activity, NAD-dependent Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Cellular Respiration Positive Regulation Of Ceramide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Regulation Of Sphingolipid Biosynthetic Process Dynein Heavy Chain Binding Dynein Light Chain Binding Outer Dynein Arm Cellular Response To Bacterial Lipopeptide NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding Response To Bacterial Lipoprotein NAD+ Binding Regulation Of Oxidoreductase Activity Dynein Axonemal Particle Outer Dynein Arm Assembly Regulation Of Membrane Lipid Metabolic Process NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Oxidative Phosphorylation Cytokine Receptor Binding Macromolecule Deacylation Glial Cell Projection NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of Aerobic Respiration Positive Regulation Of Amide Metabolic Process 9+2 Motile Cilium Innate Immune Response Dynein Complex Axonemal Dynein Complex Assembly Response To Exogenous DsRNA Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Negative Regulation Of Reactive Oxygen Species Metabolic Process	Autophagy Of Mitochondrion DNA-templated Transcription Positive Regulation Of Macrophage Apoptotic Process Nucleobase-containing Compound Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Protein Ubiquitination Stem Cell Division Protein K63-linked Ubiquitination Autophagy Cell Population Proliferation Ligase Inhibitor Activity Negative Regulation Of Post-translational Protein Modification Apoptotic Process Involved In Mammary Gland Involution Stem Cell Population Maintenance Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Response To Lipoic Acid Glycine Cleavage Complex Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Glycine Catabolic Process Response To Methylamine Limb Morphogenesis Cumulus Cell Differentiation Natriuretic Peptide Receptor Activity Vestibulocochlear Nerve Maturation Nerve Maturation C-di-GMP Signaling Granulosa Cell Differentiation Activation Of Meiosis Involved In Egg Activation Neuromuscular Process Gastric Emptying Negative Regulation Of Oocyte Maturation Microtubule Sliding 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Forebrain Development Astral Microtubule Hippocampus Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Central Region Of Growth Cone Neural Plate Development Central Nervous System Segmentation Determination Of Left/right Asymmetry In Nervous System Mitophagy Brown Fat Cell Proliferation Amphisome Atg12 Transferase Activity Atg12 Conjugating Enzyme Activity Maintenance Of Cell Number Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?