NPHP3 and DPP7

		NPHP3	DPP7
Description		nephrocystin 3	dipeptidyl peptidase 7
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GO Annotations	Cellular Component	Extracellular Region Cytosol Cilium Cell Projection Ciliary Inversin Compartment Ciliary Base	Extracellular Region Lysosome Golgi Apparatus Cytoplasmic Vesicle Vesicle Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Aminopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Hydrolase Activity Serine-type Exopeptidase Activity
	Biological Process	Kidney Development Heart Looping Atrial Septum Development Lipid Metabolic Process Establishment Or Maintenance Of Cell Polarity Determination Of Left/right Symmetry Wnt Signaling Pathway Extracellular Matrix Organization Lung Development Determination Of Pancreatic Left/right Asymmetry Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Convergent Extension Convergent Extension Involved In Gastrulation Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Kidney Morphogenesis Determination Of Intestine Left/right Asymmetry Determination Of Stomach Left/right Asymmetry Determination Of Liver Left/right Asymmetry Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Non-motile Cilium Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Proteolysis Lysosomal Protein Catabolic Process
Pathways		Trafficking of myristoylated proteins to the cilium	Neutrophil degranulation
Drugs
Diseases		Renal-hepatic-pancreatic dysplasia Meckel syndrome (MKS); Meckel-Gruber syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 21102462 27182965) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)	Pursuit maintenance gain ( 29064472)
Interacting Genes		3 interacting genes: ATXN1 DYSF NPHP1	2 interacting genes: CFTR XRN1
Entrez ID		27031	29952
HPRD ID		06417	07634
Ensembl ID		ENSG00000113971	ENSG00000176978
Uniprot IDs		Q7Z494	Q9UHL4
PDB IDs		5L7K	3JYH 3N0T 4EBB
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Nonhomologous End Joining	Epithelial Fluid Transport Fluid Transport Transepithelial Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Cellular Response To Puromycin Cellular Response To Cycloheximide Positive Regulation Of Anion Channel Activity Response To Purine-containing Compound Response To Lipid Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Response To Silicon Dioxide Maintenance Of Animal Organ Identity Ciliary Inversin Compartment 5'-3' RNA Exonuclease Activity Cellular Response To Oxygen-containing Compound Transepithelial Water Transport Determination Of Pancreatic Left/right Asymmetry Response To Cycloheximide Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Response To Ketone Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Interleukin-23 Production Histamine Secretion Ureter Development Determination Of Digestive Tract Left/right Asymmetry Convergent Extension Involved In Gastrulation Determination Of Liver Left/right Asymmetry Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Response To Alcohol Neutrophil Differentiation G-quadruplex RNA Binding Amelogenesis Histamine Transport Atrial Septum Development G-quadruplex DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Interleukin-23 Production 5'-3' Exonuclease Activity
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