NPHP4 and CIROZ

		NPHP4	CIROZ
Description		nephrocystin 4	ciliated left-right organizer protein containing ZP-N domains
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cilium Nuclear Body Photoreceptor Connecting Cilium Ciliary Transition Zone Ciliary Basal Body Cell Projection Anchoring Junction Ribbon Synapse Ciliary Base Non-motile Cilium Photoreceptor Distal Connecting Cilium	Extracellular Region
	Molecular Function	Structural Molecule Activity Protein Binding
	Biological Process	Signal Transduction Visual Behavior Actin Cytoskeleton Organization Flagellated Sperm Motility Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly Protein Localization To Ciliary Transition Zone	Establishment Of Left/right Asymmetry
Pathways		Signaling by Hippo Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS		Dimensional psychopathology (Positive) ( 29496196) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) QT interval ( 19305408) Response to taxane treatment (paclitaxel) ( 23006423)
Interacting Genes		2 interacting genes: NPHP1 RPGRIP1
Entrez ID		261734	148345
HPRD ID		06238	08780
Ensembl ID		ENSG00000131697	ENSG00000175262
Uniprot IDs		B3KW36 O75161	Q8N9H9
PDB IDs
Enriched GO Terms of Interacting Partners?		Photoreceptor Connecting Cilium	Protein Localization To Ciliary Transition Zone Ribbon Synapse Photoreceptor Distal Connecting Cilium Positive Regulation Of Bicellular Tight Junction Assembly Photoreceptor Cell Outer Segment Organization Regulation Of Bicellular Tight Junction Assembly Photoreceptor Connecting Cilium Ciliary Transition Zone Photoreceptor Cell Maintenance Non-motile Cilium Ciliary Base Visual Behavior Protein Localization To Cilium Retina Development In Camera-type Eye Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Positive Regulation Of Cell Junction Assembly Bicellular Tight Junction Sperm Motility Cilium-dependent Cell Motility Negative Regulation Of Canonical Wnt Signaling Pathway Structural Molecule Activity Cilium Movement Centriole Negative Regulation Of Wnt Signaling Pathway Cell-cell Junction Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Junction Assembly
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