PTPN20 and WDFY4

		PTPN20	WDFY4
Description		protein tyrosine phosphatase non-receptor type 20	WDFY family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Microtubule Centriolar Satellite	Endosome Early Endosome Endoplasmic Reticulum
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Hydrolase Activity	Protein Binding
	Biological Process	Lymphangiogenesis	Autophagy Antigen Processing And Presentation CD8-positive, Alpha-beta T Cell Activation Cellular Response To Virus
Pathways		Interleukin-37 signaling
Drugs
Diseases
GWAS			Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Clinically amyopathic dermatomyositis ( 29331962) Response to anti-depressant treatment in major depressive disorder ( 22041458) Rheumatoid arthritis ( 24390342 30423114 30891314) Stroke ( 26089329) Systemic lupus erythematosus ( 19838193 20169177 23273568 26502338 26606652 26663301 27399966 28714469 33272962)
Interacting Genes		6 interacting genes: AATK EGFR ERBB3 ERBB4 KIT ROR2
Entrez ID		26095	57705
HPRD ID		10898	19624
Ensembl ID		ENSG00000204179	ENSG00000128815
Uniprot IDs		Q4JDK3 Q4JDL3	A0A1W7HCV9 Q6ZS81
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex ERBB2 Signaling Pathway ATP Binding Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Tyrosine Kinase Activator Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Basolateral Plasma Membrane Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Growth Factor Binding Positive Regulation Of Receptor Signaling Pathway Via STAT Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Positive Regulation Of Peptidyl-tyrosine Phosphorylation Animal Organ Development Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process Response To Light Stimulus Multivesicular Body, Internal Vesicle Lumen Establishment Of Planar Polarity Involved In Nephron Morphogenesis Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction JUN Phosphorylation Clathrin-coated Endocytic Vesicle Membrane	Lymphangiogenesis
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