ABHD14A and DNAH1

		ABHD14A	DNAH1
Description		abhydrolase domain containing 14A	dynein axonemal heavy chain 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Extracellular Region Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Sperm Flagellum Inner Dynein Arm Cell Projection
	Molecular Function	Hydrolase Activity	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process		Epithelial Cilium Movement Involved In Extracellular Fluid Movement Microtubule-based Movement Sperm Axoneme Assembly Flagellated Sperm Motility Inner Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility
Pathways
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Chronotype ( 30696823) Electroencephalogram traits ( 25387704) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol ( 30275531) Parkinson's disease ( 28892059) Schizophrenia ( 23974872) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: F2RL1 GPR35 RUNX1
Entrez ID		25864	25981
HPRD ID		08530	11790
Ensembl ID		ENSG00000248487	ENSG00000114841
Uniprot IDs		Q9BUJ0	A0A140VJI6 Q9P2D7
PDB IDs			8I3J 8J07
Enriched GO Terms of Interacting Partners?		Core-binding Factor Complex Myeloid Leukocyte Differentiation Proteinase-activated Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Cardiac Muscle Tissue Regeneration Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Mature Conventional Dendritic Cell Differentiation Positive Regulation Of Killing Of Cells Of Another Organism Thrombin-activated Receptor Activity Inner Dynein Arm Myeloid Cell Differentiation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Toll-like Receptor 2 Signaling Pathway C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Leukocyte Differentiation Peripheral Nervous System Neuron Development Regulation Of Connective Tissue Replacement Negative Regulation Of Granulocyte Differentiation Regulation Of Toll-like Receptor 3 Signaling Pathway Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly G Protein-coupled Receptor Activity Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Glomerular Filtration Axonemal Dynein Complex Regulation Of Voltage-gated Calcium Channel Activity Minus-end-directed Microtubule Motor Activity Negative Regulation Of Transport Regulation Of Granulocyte Differentiation Inner Dynein Arm Assembly Regulation Of Plasminogen Activation Regulation Of Defense Response To Bacterium Pseudopodium Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Protein Depolymerization	DNA/RNA Helicase Activity RNA Binding TRNA Processing Growth Plate Cartilage Chondrocyte Development Positive Regulation Of Centrosome Duplication Chondrocyte Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Protein Localization To Chromosome, Telomeric Region O-phosphoseryl-tRNA(Sec) Selenium Transferase Activity Conversion Of Seryl-tRNAsec To Selenocys-tRNAsec MPP7-DLG1-LIN7 Complex
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