MMS22L and RARS2

		MMS22L	RARS2
Description		MMS22 like, DNA repair protein	arginyl-tRNA synthetase 2, mitochondrial
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol FACT Complex Site Of Double-strand Break MCM Complex Nuclear Replication Fork Site Of DNA Damage	Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Mitochondrial Membrane
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding	Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Arginine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization DNA Damage Response Replication Fork Processing Protein Localization To Chromatin	TRNA Metabolic Process Translation TRNA Aminoacylation For Protein Translation Arginyl-tRNA Aminoacylation Gene Expression Mitochondrial Translation
Pathways			Mitochondrial tRNA aminoacylation
Drugs
Diseases			Pontocerebellar hypoplasia
GWAS		Adult body size ( 32376654) Anxiety ( 33859377) Automobile speeding propensity ( 30643258) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Chronotype ( 30696823) Gut microbiota (bacterial taxa) ( 27694959) Hand grip strength ( 29691431) Morning person ( 30696823) Multiple sclerosis (OCB status) ( 23785401) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232) Household income (MTAG) ( 31844048) Initial alcohol sensitivity ( 30276832) Obesity-related traits ( 23251661)
Interacting Genes		4 interacting genes: ESCO2 FBXW7 RAD51 RPA1	1 interacting genes: OGT
Entrez ID		253714	57038
HPRD ID		12865	15209
Ensembl ID		ENSG00000146263	ENSG00000146282
Uniprot IDs		E2QRD4 Q6ZRQ5	A0A8I5KPZ0 A0A8I5KWC6 H0UI22 Q5T160
PDB IDs
Enriched GO Terms of Interacting Partners?		Lateral Element Site Of Double-strand Break Chromosome Organization Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cellular Response To Stress Condensed Chromosome Response To Glucoside Double-strand Break Repair Condensed Nuclear Chromosome DNA Repair Male Germ Cell Nucleus Negative Regulation Of Establishment Of Blood-brain Barrier Sister Chromatid Cohesion Positive Regulation Of Translational Initiation In Response To Stress Response To Unfolded Protein Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Mitotic Recombination-dependent Replication Fork Processing DNA Metabolic Process DNA Damage Response DNA Strand Exchange Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Presynaptic Intermediate Filament Cytoskeleton Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Dendritic Transport Of Mitochondrion Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Arginyl-tRNA Aminoacylation Arginine-tRNA Ligase Activity Post-translational Protein Acetylation Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Meiotic Cell Cycle DNA Strand Invasion Telomere Maintenance Single-stranded DNA Binding DNA Recombinase Assembly Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Toxic Substance PML Body Single-stranded Telomeric DNA Binding Protein Localization To Chromosome Vitamin E Metabolic Process Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Ubiquitin Recycling	Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity FACT Complex Regulation Of Transcription By Glucose NSL Complex MCM Complex Protein Localization To Organelle Acetylglucosaminyltransferase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Nuclear Replication Fork Chromatin Organization Sin3-type Complex Histone Acetyltransferase Complex Negative Regulation Of Stem Cell Population Maintenance Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Regulation Of Necroptotic Process Regulation Of Rac Protein Signal Transduction Mitophagy Protein Localization To Lysosome Circadian Regulation Of Gene Expression Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Glucose Stimulus Regulation Of Stem Cell Population Maintenance Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Gluconeogenesis Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Positive Regulation Of TORC1 Signaling Cellular Response To Carbohydrate Stimulus Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Phosphatidylinositol-3,4,5-trisphosphate Binding Pyroptotic Inflammatory Response Cellular Response To Nutrient Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Autophagy Of Mitochondrion Positive Regulation Of Translational Initiation Negative Regulation Of Protein Ubiquitination TORC1 Signaling Regulation Of Insulin Receptor Signaling Pathway Regulation Of Programmed Necrotic Cell Death Replication Fork Processing
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