MMS22L and NDUFAF4

		MMS22L	NDUFAF4
Description		MMS22 like, DNA repair protein	NADH:ubiquinone oxidoreductase complex assembly factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol FACT Complex Site Of Double-strand Break MCM Complex Nuclear Replication Fork Site Of DNA Damage	Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane Mitochondrial Membrane
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding	Protein Binding Calmodulin Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization DNA Damage Response Replication Fork Processing Protein Localization To Chromatin	NADH Dehydrogenase Complex Assembly Mitochondrial Respiratory Chain Complex I Assembly Defense Response To Virus
Pathways			Complex I biogenesis
Drugs
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Adult body size ( 32376654) Anxiety ( 33859377) Automobile speeding propensity ( 30643258) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Chronotype ( 30696823) Gut microbiota (bacterial taxa) ( 27694959) Hand grip strength ( 29691431) Morning person ( 30696823) Multiple sclerosis (OCB status) ( 23785401) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		4 interacting genes: ESCO2 FBXW7 RAD51 RPA1
Entrez ID		253714	29078
HPRD ID		12865	10795
Ensembl ID		ENSG00000146263	ENSG00000123545
Uniprot IDs		E2QRD4 Q6ZRQ5	Q9P032
PDB IDs
Enriched GO Terms of Interacting Partners?		Lateral Element Site Of Double-strand Break Chromosome Organization Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome Positive Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cellular Response To Stress Condensed Chromosome Response To Glucoside Double-strand Break Repair Condensed Nuclear Chromosome DNA Repair Male Germ Cell Nucleus Negative Regulation Of Establishment Of Blood-brain Barrier Sister Chromatid Cohesion Positive Regulation Of Translational Initiation In Response To Stress Response To Unfolded Protein Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Mitotic Recombination-dependent Replication Fork Processing DNA Metabolic Process DNA Damage Response DNA Strand Exchange Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Presynaptic Intermediate Filament Cytoskeleton Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Dendritic Transport Of Mitochondrion Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Arginyl-tRNA Aminoacylation Arginine-tRNA Ligase Activity Post-translational Protein Acetylation Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Meiotic Cell Cycle DNA Strand Invasion Telomere Maintenance Single-stranded DNA Binding DNA Recombinase Assembly Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Toxic Substance PML Body Single-stranded Telomeric DNA Binding Protein Localization To Chromosome Vitamin E Metabolic Process Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Ubiquitin Recycling	FACT Complex MCM Complex Nuclear Replication Fork Replication Fork Processing Site Of DNA Damage Protein Localization To Chromatin Site Of Double-strand Break Protein Localization To Chromosome Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Recombination
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