MTCH1 and NQO2

		MTCH1	NQO2
Description		mitochondrial carrier 1	N-ribosyldihydronicotinamide:quinone dehydrogenase 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Membrane Insertase Activity	Dihydronicotinamide Riboside Quinone Reductase Activity NAD(P)H Dehydrogenase (quinone) Activity Protein Binding Zinc Ion Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Chloride Ion Binding Protein Homodimerization Activity Metal Ion Binding FAD Binding Melatonin Binding Resveratrol Binding
	Biological Process	Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Outer Membrane Neuronal Ion Channel Clustering	Quinone Catabolic Process
Pathways			Phase I - Functionalization of compounds
Drugs			NADH Menadione Melatonin Primaquine Resveratrol Flavin adenine dinucleotide 10-Propargyl-5,8-Dideazafolic Acid Quercetin Tretazicar (3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one Casimiroin
Diseases
GWAS		Acne (severe) ( 24927181) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678)	Blood protein levels ( 30072576) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		5 interacting genes: APLNR ERBB2 GSK3A PSEN1 UBC	7 interacting genes: DDIT4L DGCR6 EFHC1 GORASP2 IL32 LRRC7 SPG21
Entrez ID		23787	4835
HPRD ID		14787	01190
Ensembl ID		ENSG00000137409	ENSG00000124588
Uniprot IDs		A0A8Q3WKC8 A8YXX5 H0Y8C3 Q9NZJ7	B3KPX6 P16083 Q5TD07
PDB IDs			1QR2 1SG0 1XI2 1ZX1 2BZS 2QMY 2QMZ 2QR2 2QWX 2QX4 2QX6 2QX8 2QX9 3FW1 3G5M 3GAM 3NFR 3NHF 3NHJ 3NHK 3NHL 3NHP 3NHR 3NHS 3NHU 3NHW 3NHY 3O2N 3O73 3OVM 3OWH 3OWX 3OX1 3OX2 3OX3 3TE7 3TEM 3TZB 3UXE 3UXH 4FGJ 4FGK 4FGL 4GQI 4GR9 4QOD 4QOE 4QOF 4QOG 4QOH 4QOI 4QOJ 4U7F 4U7G 4U7H 4XDG 4XDH 4ZVK 4ZVL 4ZVM 4ZVN 5BUC 5LBT 5LBU 5LBW 5LBY 5LBZ 7O4D
Enriched GO Terms of Interacting Partners?		Heart Development Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Muscle Hypertrophy Mechanoreceptor Activity Apelin Receptor Activity Heart Looping Embryonic Heart Tube Morphogenesis Regulation Of Cardiac Muscle Hypertrophy Apelin Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy Calcium-dependent ATPase Activity Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Apoptotic Signaling Pathway ERBB3:ERBB2 Complex Neuromuscular Junction Negative Regulation Of Cell Development Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of UDP-glucose Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Quinone Catabolic Process Melatonin Binding Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Dihydronicotinamide Riboside Quinone Reductase Activity Resveratrol Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Negative Regulation Of Core Promoter Binding Glutamine Synthetase Activity Glutamine Biosynthetic Process Nitrogen Utilization Positive Regulation Of G Protein-coupled Receptor Internalization RNA Polymerase I Core Binding NAD(P)H Dehydrogenase (quinone) Activity Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Epithelial Tube Morphogenesis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of L-glutamate Import Across Plasma Membrane Synaptic Vesicle Targeting Astrocyte Activation Involved In Immune Response
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