MTCH1 and EML4

		MTCH1	EML4
Description		mitochondrial carrier 1	EMAP like 4
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Cytoplasm Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Membrane Midbody Intercellular Bridge Mitotic Spindle
	Molecular Function	Protein Binding Membrane Insertase Activity	Protein Binding Microtubule Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Outer Membrane Neuronal Ion Channel Clustering	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Mitotic Metaphase Chromosome Alignment Attachment Of Spindle Microtubules To Kinetochore Cell Division
Pathways			EML4 and NUDC in mitotic spindle formation ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases			Non-small cell lung cancer
GWAS		Acne (severe) ( 24927181) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678)	Chronic obstructive pulmonary disease ( 30804561) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 30061609) Metabolite levels ( 23823483) PR interval ( 32439900) Type 2 diabetes ( 31118516)
Interacting Genes		5 interacting genes: APLNR ERBB2 GSK3A PSEN1 UBC	6 interacting genes: ARIH2 ARL4D NEK6 NEK7 TUBA1B TUBB
Entrez ID		23787	27436
HPRD ID		14787	06310
Ensembl ID		ENSG00000137409	ENSG00000143924
Uniprot IDs		A0A8Q3WKC8 A8YXX5 H0Y8C3 Q9NZJ7	B5MBZ0 Q9HC35
PDB IDs			4CGC
Enriched GO Terms of Interacting Partners?		Heart Development Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Muscle Hypertrophy Mechanoreceptor Activity Apelin Receptor Activity Heart Looping Embryonic Heart Tube Morphogenesis Regulation Of Cardiac Muscle Hypertrophy Apelin Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Hypertrophy Calcium-dependent ATPase Activity Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Apoptotic Signaling Pathway ERBB3:ERBB2 Complex Neuromuscular Junction Negative Regulation Of Cell Development Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of UDP-glucose Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Quinone Catabolic Process Melatonin Binding Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Dihydronicotinamide Riboside Quinone Reductase Activity Resveratrol Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Negative Regulation Of Core Promoter Binding Glutamine Synthetase Activity Glutamine Biosynthetic Process Nitrogen Utilization Positive Regulation Of G Protein-coupled Receptor Internalization RNA Polymerase I Core Binding NAD(P)H Dehydrogenase (quinone) Activity Protein Catabolic Process At Postsynapse Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Epithelial Tube Morphogenesis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of L-glutamate Import Across Plasma Membrane Synaptic Vesicle Targeting Astrocyte Activation Involved In Immune Response	Microtubule Spindle Assembly Microtubule Cytoskeleton Organization Spindle Organization Nucleotide Binding Ubiquitin Protein Ligase Binding Microtubule-based Process Membraneless Organelle Assembly GTPase Activity GTP Binding Cytoskeleton Organization Cell Division Structural Constituent Of Cytoskeleton Protein Localization To Extracellular Region Protein Secretion Establishment Of Protein Localization To Extracellular Region Organelle Organization Mitotic Cell Cycle Cytoskeleton Cellular Localization Establishment Of Localization In Cell Spindle Pole Structural Molecule Activity Organelle Assembly Cytoskeleton-dependent Intracellular Transport Odontoblast Differentiation Microtubule Cytoskeleton Mitotic Nuclear Membrane Disassembly Regulation Of Chromosome Organization Neuronal Ion Channel Clustering Positive Regulation Of Interleukin-18 Production GTPase Activating Protein Binding Nuclear Envelope Lumen Protein Insertion Into Mitochondrial Outer Membrane Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Cellular Response To Potassium Ion Cul5-RING Ubiquitin Ligase Complex Nuclear Membrane Disassembly Membrane Disassembly Membrane Insertase Activity MHC Class I Protein Binding
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