MDN1 and FADS3

		MDN1	FADS3
Description		midasin AAA ATPase 1	fatty acid desaturase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Intermediate Filament Cytoskeleton	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water
	Biological Process	Ribosomal Large Subunit Assembly Ribosome Biogenesis	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Sphingolipid Metabolic Process Gene Expression
Pathways
Drugs
Diseases
GWAS		Asthma ( 31959851) Coronary artery disease ( 29212778) QRS interval (sulfonylurea treatment interaction) ( 27958378)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma (adult onset) ( 31036433) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Cholesterol, total ( 24097068 19060911 20686565 25961943) Fatty acid desaturase activity (serum) ( 30453627) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 25961943 20686565 19060906 19060911 24097068) HDL cholesterol levels ( 28334899) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 20686565 25961943 19060911 24097068) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 23378610 22916037 23823483) Oleic acid (18:1n-9) levels ( 23362303) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 30423114 24390342) Serum metabolite levels (CMS) ( 31636271) Sphingolipid d18:1/d18:2 ratio ( 31862735) Sphingolipid levels ( 22359512 19798445) Stearic acid (18:0) levels ( 23362303) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 25961943 24097068 20686565 19060906) Urate levels ( 31578528)
Interacting Genes		5 interacting genes: AR PTEN SUMO2 UBC USP7	1 interacting genes: DHRSX
Entrez ID		23195	3995
HPRD ID		10069	07547
Ensembl ID		ENSG00000112159	ENSG00000221968
Uniprot IDs		Q9NU22	E9PKP8 Q9Y5Q0
PDB IDs
Enriched GO Terms of Interacting Partners?		PML Body Protein Tag Activity	Dolichal Reductase (NADPH) Activity Polyprenol Dehydrogenase (NAD+) Activity Dolichyl Monophosphate Biosynthetic Process Ribosomal Large Subunit Assembly
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