HS3ST5 and RSPH4A

		HS3ST5	RSPH4A
Description		heparan sulfate-glucosamine 3-sulfotransferase 5	radial spoke head component 4A
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Radial Spoke Radial Spoke Head Extracellular Region Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Cell Projection 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 2 Radial Spoke Head 3
	Molecular Function	Protein Binding Sulfotransferase Activity [heparan Sulfate]-glucosamine 3-sulfotransferase Activity Transferase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding
	Biological Process	Protein Sulfation Heparan Sulfate Proteoglycan Biosynthetic Process Regulation Of Viral Entry Into Host Cell Negative Regulation Of Coagulation	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Cell Projection Organization Axoneme Assembly Establishment Of Localization In Cell Cilium Assembly Cilium Movement Involved In Cell Motility Radial Spoke Assembly Maintenance Of Ciliary Planar Beating Movement Pattern
Pathways		HS-GAG biosynthesis
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Body mass index ( 25673413) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime nap ( 33568662) Gray matter volume (schizophrenia interaction) ( 24086445)
Interacting Genes
Entrez ID		222537	345895
HPRD ID		13674	18005
Ensembl ID		ENSG00000249853	ENSG00000111834
Uniprot IDs		Q8IZT8	B3KTA9 Q5TD94
PDB IDs		3BD9 7SCD 7SCE	8J07
Enriched GO Terms of Interacting Partners?		Radial Spoke Head 2 Maintenance Of Ciliary Planar Beating Movement Pattern Radial Spoke Head 1 Radial Spoke Assembly Radial Spoke Head 3 Radial Spoke Head Radial Spoke 9+2 Motile Cilium Regulation Of Cilium Movement Axoneme Assembly Extracellular Transport Epithelial Cilium Movement Involved In Extracellular Fluid Movement Regulation Of Microtubule-based Movement Microtubule Bundle Formation Axoneme Cilium Movement Involved In Cell Motility Cilium Movement Microtubule-based Transport Motile Cilium Regulation Of Microtubule-based Process Cilium Assembly Cilium Organization Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Microtubule-based Movement	ATP Export ATP Transport Purine Nucleotide Transport Adenine Nucleotide Transport Monoatomic Cation Channel Activity Nucleotide Transport Carbohydrate Derivative Transport [heparan Sulfate]-glucosamine 3-sulfotransferase Activity Protein Sulfation Mitochondrial Protein Quality Control Organophosphate Ester Transport Voltage-gated Channel Activity Nucleobase-containing Compound Transport 3'-phosphoadenosine 5'-phosphosulfate Binding Mitochondrial Protein Catabolic Process Regulation Of Natural Killer Cell Cytokine Production Organic Anion Transport Sulfation Regulation Of Viral Entry Into Host Cell Heparan Sulfate Proteoglycan Biosynthetic Process
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