ZUP1 and RSPH4A

		ZUP1	RSPH4A
Description		zinc finger containing ubiquitin peptidase 1	radial spoke head component 4A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Radial Spoke Radial Spoke Head Extracellular Region Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Cell Projection 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 2 Radial Spoke Head 3
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process		Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Cell Projection Organization Axoneme Assembly Establishment Of Localization In Cell Cilium Assembly Cilium Movement Involved In Cell Motility Radial Spoke Assembly Maintenance Of Ciliary Planar Beating Movement Pattern
Pathways
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS
Interacting Genes		9 interacting genes: ARHGAP45 CDKN2A CFTR CLN8 MMP14 PRMT5 RPS21 SHCBP1 UBC
Entrez ID		221302	345895
HPRD ID		12840	18005
Ensembl ID		ENSG00000153975	ENSG00000111834
Uniprot IDs		A0A0S2Z644 Q96AP4	B3KTA9 Q5TD94
PDB IDs		6EI1 6FGE	8J07
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell-matrix Adhesion Ligase Inhibitor Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Radial Spoke Head 2 Maintenance Of Ciliary Planar Beating Movement Pattern Positive Regulation Of Macrophage Apoptotic Process P53 Binding Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Protein Metabolic Process Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Regulation Of B Cell Activation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Proteolysis Senescence-associated Heterochromatin Focus Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell-matrix Adhesion Apoptotic Process Involved In Mammary Gland Involution Cytoplasm Regulation Of Signal Transduction By P53 Class Mediator Sterol Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Positive Regulation Of Monoatomic Anion Transport Somatic Motor Neuron Differentiation Glutamate Reuptake Retinal Rod Cell Apoptotic Process Response To Genistein GDF15-GFRAL Signaling Pathway Response To Hydroxyisoflavone Macropinosome Response To Odorant Histone H4R3 Methyltransferase Activity Peptidyl-arginine N-methylation Positive Regulation Of Dopamine Receptor Signaling Pathway Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Peptidyl-arginine Methylation Radial Spoke Head 1 Radial Spoke Assembly	ATP Export ATP Transport Purine Nucleotide Transport Adenine Nucleotide Transport Monoatomic Cation Channel Activity Nucleotide Transport Carbohydrate Derivative Transport [heparan Sulfate]-glucosamine 3-sulfotransferase Activity Protein Sulfation Mitochondrial Protein Quality Control Organophosphate Ester Transport Voltage-gated Channel Activity Nucleobase-containing Compound Transport 3'-phosphoadenosine 5'-phosphosulfate Binding Mitochondrial Protein Catabolic Process Regulation Of Natural Killer Cell Cytokine Production Organic Anion Transport Sulfation Regulation Of Viral Entry Into Host Cell Heparan Sulfate Proteoglycan Biosynthetic Process
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