IDO2 and SMIM19

		IDO2	SMIM19
Description		indoleamine 2,3-dioxygenase 2	small integral membrane protein 19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Membrane
	Molecular Function	Tryptophan 2,3-dioxygenase Activity Protein Binding Oxidoreductase Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding Dioxygenase Activity	Protein Binding
	Biological Process	Immune System Process L-tryptophan Catabolic Process L-tryptophan Catabolic Process To Kynurenine 'de Novo' NAD+ Biosynthetic Process From L-tryptophan
Pathways		Tryptophan catabolism
Drugs
Diseases
GWAS		Schizophrenia x sex interaction ( 34099189)	Age at first sexual intercourse ( 34211149) Brain morphology (MOSTest) ( 32665545) Gut microbiota (functional units) ( 27694959) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin concentration ( 28453575)
Interacting Genes		2 interacting genes: BANP LZTS1	5 interacting genes: ASPH GET3 JAGN1 UBQLN1 UBQLN2
Entrez ID		169355	114926
HPRD ID		14113	14005
Ensembl ID		ENSG00000188676	ENSG00000176209
Uniprot IDs		Q6ZQW0	Q96E16
PDB IDs
Enriched GO Terms of Interacting Partners?			Positive Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Dioxygenase Activity Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Negative Regulation Of Transport Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Autophagosome Organization Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Indoleamine 2,3-dioxygenase Activity Endoplasmic Reticulum GET Complex Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Tryptophan 2,3-dioxygenase Activity Negative Regulation Of Clathrin-dependent Endocytosis Vacuole Organization Activation Of Store-operated Calcium Channel Activity Granulocyte Colony-stimulating Factor Signaling Pathway L-tryptophan Catabolic Process To Kynurenine Positive Regulation Of Protein Metabolic Process Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Protein Catabolic Process Regulation Of Calcium Ion Transport Cortical Endoplasmic Reticulum Neutrophil Differentiation Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus 'de Novo' NAD+ Biosynthetic Process From L-tryptophan L-tryptophan Catabolic Process Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Regulation Of Monoatomic Cation Transmembrane Transport Kynurenine Metabolic Process Endoplasmic Reticulum Membrane
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