DDX10 and ARHGAP20

		DDX10	ARHGAP20
Description		DEAD-box helicase 10	Rho GTPase activating protein 20
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Cytosol
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	GTPase Activator Activity
	Biological Process	RRNA Processing Anterior Head Development	Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways			RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 34099189) Femur bone mineral density x serum urate levels interaction ( 34046847) Knee osteoarthritis ( 28916551) Systolic blood pressure ( 27841878)	Alzheimer's disease (cognitive decline) ( 23535033) Central corneal thickness ( 29760442 30894546) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Corneal structure ( 23291589) Coronary artery disease ( 32469254) Cutaneous melanoma or hair colour ( 32341527) Intraocular pressure ( 29617998 29785010) Lateral ventricular volume in normal aging ( 30258056) Lean body mass ( 28552196) Metabolite levels ( 23823483) Renal sinus fat ( 22044751) Serum metabolite levels ( 33031748)
Interacting Genes		4 interacting genes: APP FBXO7 RNF10 SIRPA	3 interacting genes: CDC42 RAC1 RHOA
Entrez ID		1662	57569
HPRD ID		03138	10657
Ensembl ID		ENSG00000178105	ENSG00000137727
Uniprot IDs		Q13206	Q9P2F6
PDB IDs		2PL3	3MSX
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of System Process Lipoprotein Particle Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Import Regulation Of Nitric Oxide Metabolic Process Insulin-like Growth Factor Binary Complex Maintenance Of Protein Location In Nucleus Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location Maintenance Of Protein Location In Cell 6-pyruvoyltetrahydropterin Synthase Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Symbiont-mediated Suppression Of Host Innate Immune Response SCF Ubiquitin Ligase Complex GTPase Regulator Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Carotene Metabolic Process Xanthophyll Catabolic Process Zeaxanthin Catabolic Process Carotenoid Dioxygenase Activity 9,10 (9', 10')-carotenoid-cleaving Dioxygenase Activity Lutein Catabolic Process Beta,beta-carotene-9',10'-cleaving Oxygenase Activity Carotene Catabolic Process Xanthophyll Metabolic Process Lycopene Catabolic Process Cellular Response To Interleukin-12 PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Maintenance Of Location In Cell Maintenance Of Location	Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Stress Fiber Assembly Regulation Of Protein-containing Complex Assembly Thioesterase Binding Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Establishment Of Epithelial Cell Apical/basal Polarity Nucleotide Binding Cell-cell Junction Organization Positive Regulation Of Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Positive Regulation Of Protein-containing Complex Assembly Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Postsynapse Positive Regulation Of Lamellipodium Assembly Establishment Of Epithelial Cell Polarity Cerebral Cortex Cell Migration Phagocytosis, Engulfment Actin Filament Organization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Wnt Signaling Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Regulation Of Cell Migration Regulation Of Synapse Organization Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Regulation Of Cell Motility GTPase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development
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