DDX10 and ARL2BP

		DDX10	ARL2BP
Description		DEAD-box helicase 10	ARF like GTPase 2 binding protein
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Centrosome Spindle Cytosol Cytoskeleton Cilium Midbody Ciliary Basal Body Cell Projection
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Transcription Coactivator Activity Protein Binding GTPase Regulator Activity
	Biological Process	RRNA Processing Anterior Head Development	Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of DNA-templated Transcription Maintenance Of Protein Location In Nucleus
Pathways			Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Drugs
Diseases
GWAS		Bipolar disorder ( 34099189) Femur bone mineral density x serum urate levels interaction ( 34046847) Knee osteoarthritis ( 28916551) Systolic blood pressure ( 27841878)	Mean corpuscular hemoglobin concentration ( 29403010)
Interacting Genes		4 interacting genes: APP FBXO7 RNF10 SIRPA	6 interacting genes: ARL2 ARL3 CAMK2D CFAP20 MPP3 RAC1
Entrez ID		1662	23568
HPRD ID		03138	09808
Ensembl ID		ENSG00000178105	ENSG00000102931
Uniprot IDs		Q13206	Q9Y2Y0
PDB IDs		2PL3	2K9A 3DOE 3DOF
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of System Process Lipoprotein Particle Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Import Regulation Of Nitric Oxide Metabolic Process Insulin-like Growth Factor Binary Complex Maintenance Of Protein Location In Nucleus Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location Maintenance Of Protein Location In Cell 6-pyruvoyltetrahydropterin Synthase Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Symbiont-mediated Suppression Of Host Innate Immune Response SCF Ubiquitin Ligase Complex GTPase Regulator Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Carotene Metabolic Process Xanthophyll Catabolic Process Zeaxanthin Catabolic Process Carotenoid Dioxygenase Activity 9,10 (9', 10')-carotenoid-cleaving Dioxygenase Activity Lutein Catabolic Process Beta,beta-carotene-9',10'-cleaving Oxygenase Activity Carotene Catabolic Process Xanthophyll Metabolic Process Lycopene Catabolic Process Cellular Response To Interleukin-12 PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Maintenance Of Location In Cell Maintenance Of Location	Nucleotide Binding Regulation Of Microtubule-based Process Regulation Of Microtubule Polymerization GTPase Activity Positive Regulation Of Microtubule Polymerization Ciliary Basal Body GTP Binding Cell Projection Assembly Plasma Membrane Bounded Cell Projection Assembly Regulation Of Neuronal Synaptic Plasticity Placental Growth Factor Receptor Activity Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway GDP Binding Positive Regulation Of Protein Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell-substrate Adhesion Cytoskeleton Cilium Neuron Development Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Relaxation Of Cardiac Muscle Regulation Of Protein Localization To Membrane Anterior Head Development Hyaloid Vascular Plexus Regression Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Ovarian Follicle Development Auditory Receptor Cell Morphogenesis Erythrocyte Enucleation Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Protein Polyglutamylation Cell-cell Junction Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytoskeleton Organization Protein Localization To Ciliary Membrane Sodium Channel Inhibitor Activity Regulation Of Synaptic Plasticity
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