DENND1B and ZBTB41

		DENND1B	ZBTB41
Description		DENN domain containing 1B	zinc finger and BTB domain containing 41
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Speck Clathrin-coated Vesicle Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Nucleus
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Phosphatidylinositol Phosphate Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Endocytosis Protein Transport Endocytic Recycling Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production	Regulation Of Transcription By RNA Polymerase II
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)	Age-related macular degeneration ( 23536807) Lupus nephritis in systemic lupus erythematosus ( 24925725)
Interacting Genes		7 interacting genes: ARF1 ARF4 ARF5 HOOK1 LNX1 RAB35 RBFOX2
Entrez ID		163486	360023
HPRD ID		13303	17017
Ensembl ID		ENSG00000213047	ENSG00000177888
Uniprot IDs		Q6P3S1	Q5SVQ8
PDB IDs		3TW8
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Establishment Of Localization In Cell Vesicle-mediated Transport Protein Transport Intracellular Transport Mitotic Cleavage Furrow Ingression Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Arsenate Reductase (glutaredoxin) Activity Chloride-activated Potassium Channel Activity Intracellular Sodium-activated Potassium Channel Activity Establishment Of Protein Localization Cleavage Furrow Ingression Phospholipase D Activator Activity Glutathione Disulfide Oxidoreductase Activity Cellular Localization	Interleukin-1-mediated Signaling Pathway Response To Potassium Ion Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Cellular Response To Potassium Ion Protein Transport Positive Regulation Of Interleukin-18 Production Canonical Inflammasome Complex Assembly NLRP3 Inflammasome Complex Assembly Molecular Function Activator Activity Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 2 Cell Cytokine Production Phosphatidylinositol Phosphate Binding Regulation Of Type 2 Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Gene Expression Pyroptotic Inflammatory Response Regulation Of T Cell Cytokine Production Establishment Of Protein Localization Regulation Of NLRP3 Inflammasome Complex Assembly
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