DENND1B and KCNT2

		DENND1B	KCNT2
Description		DENN domain containing 1B	potassium sodium-activated channel subfamily T member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Speck Clathrin-coated Vesicle Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Plasma Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Phosphatidylinositol Phosphate Binding	Intracellular Sodium-activated Potassium Channel Activity Potassium Channel Activity Outward Rectifier Potassium Channel Activity Chloride-activated Potassium Channel Activity
	Biological Process	Endocytosis Protein Transport Endocytic Recycling Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)	Adult body size ( 32376654) Age-related macular degeneration ( 23536807 23577725) Age-related macular degeneration (extreme sampling) ( 23577725) Body size at age 10 ( 32376654) Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Idiopathic dilated cardiomyopathy ( 29495422) Lung cancer in ever smokers ( 28604730) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 ( 26634245) Takayasu arteritis ( 25604533) Total ventricular volume ( 21116278) Waist-hip index ( 34021172)
Interacting Genes		7 interacting genes: ARF1 ARF4 ARF5 HOOK1 LNX1 RAB35 RBFOX2
Entrez ID		163486	343450
HPRD ID		13303	11584
Ensembl ID		ENSG00000213047	ENSG00000162687
Uniprot IDs		Q6P3S1	A0A3B3IRL4 A9LNM6 Q6UVM3
PDB IDs		3TW8
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Establishment Of Localization In Cell Vesicle-mediated Transport Protein Transport Intracellular Transport Mitotic Cleavage Furrow Ingression Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Arsenate Reductase (glutaredoxin) Activity Chloride-activated Potassium Channel Activity Intracellular Sodium-activated Potassium Channel Activity Establishment Of Protein Localization Cleavage Furrow Ingression Phospholipase D Activator Activity Glutathione Disulfide Oxidoreductase Activity Cellular Localization	Positive Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 2 Cell Cytokine Production Phosphatidylinositol Phosphate Binding Regulation Of Type 2 Immune Response Positive Regulation Of Type 2 Immune Response Regulation Of T Cell Cytokine Production Vesicle-mediated Transport To The Plasma Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Vesicle T Cell Receptor Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Mediated Immunity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Receptor-mediated Signaling Pathway Endocytic Recycling Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Regulation Of Production Of Molecular Mediator Of Immune Response Guanyl-nucleotide Exchange Factor Activity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Positive Regulation Of Immune Effector Process Small GTPase Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endosomal Transport
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