DENND1B and ATP6V1G3

		DENND1B	ATP6V1G3
Description		DENN domain containing 1B	ATPase H+ transporting V1 subunit G3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Speck Clathrin-coated Vesicle Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle	Vacuolar Proton-transporting V-type ATPase, V1 Domain Cytosol Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Synaptic Vesicle Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Phosphatidylinositol Phosphate Binding	Protein Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Endocytosis Protein Transport Endocytic Recycling Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production	Monoatomic Ion Transport Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		RAB GEFs exchange GTP for GDP on RABs	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS		Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)	Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) ( 23648065) Asthma ( 31959851) Body mass index ( 28552196) General risk tolerance (MTAG) ( 30643258) Mean corpuscular hemoglobin ( 20139978 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Multiple sclerosis ( 31604244) Red blood cell count ( 29403010)
Interacting Genes		7 interacting genes: ARF1 ARF4 ARF5 HOOK1 LNX1 RAB35 RBFOX2	1 interacting genes: OTX2
Entrez ID		163486	127124
HPRD ID		13303	16526
Ensembl ID		ENSG00000213047	ENSG00000151418
Uniprot IDs		Q6P3S1	Q96LB4
PDB IDs		3TW8
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Establishment Of Localization In Cell Vesicle-mediated Transport Protein Transport Intracellular Transport Mitotic Cleavage Furrow Ingression Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Arsenate Reductase (glutaredoxin) Activity Chloride-activated Potassium Channel Activity Intracellular Sodium-activated Potassium Channel Activity Establishment Of Protein Localization Cleavage Furrow Ingression Phospholipase D Activator Activity Glutathione Disulfide Oxidoreductase Activity Cellular Localization
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