LRRC74A and PROX2

		LRRC74A	PROX2
Description		leucine rich repeat containing 74A	prospero homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Cytoplasm
	Molecular Function		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding
	Biological Process		Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Pancreas Development Tube Development Cell Fate Commitment Positive Regulation Of Cell Cycle Anatomical Structure Formation Involved In Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Lymphatic Endothelial Cell Differentiation Lens Fiber Cell Morphogenesis Hepatocyte Differentiation
Pathways
Drugs
Diseases
GWAS		Type 2 diabetes ( 32499647)	Depression ( 29700475) Gastroesophageal reflux disease ( 34187846) Monocyte count ( 32888494) Mood instability ( 29187730) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Total cholesterol levels ( 29083408)
Interacting Genes
Entrez ID		145497	283571
HPRD ID		12621	19081
Ensembl ID		ENSG00000100565	ENSG00000119608
Uniprot IDs		A0A8I5KUH5 A0A8I5KW16 Q0VAA2	G3V3G0 Q3B8N5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of L-glutamate Import Across Plasma Membrane Sequestering Of Calcium Ion Synaptic Vesicle Targeting Protein Catabolic Process At Postsynapse Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Amyloid Fibril Formation Embryonic Morphogenesis Cajal-Retzius Cell Differentiation Negative Regulation Of Core Promoter Binding Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Growth Factor Receptor Binding Negative Regulation Of Transcription Regulatory Region DNA Binding Astrocyte Activation Involved In Immune Response Lens Fiber Cell Morphogenesis Lymphatic Endothelial Cell Differentiation Embryonic Retina Morphogenesis In Camera-type Eye Regulation Of L-glutamate Import Across Plasma Membrane Choline Transport Ciliary Rootlet Notch Receptor Processing Amyloid-beta Formation Skin Morphogenesis Endoplasmic Reticulum Calcium Ion Homeostasis Amyloid Precursor Protein Catabolic Process Vesicle Targeting Myeloid Dendritic Cell Differentiation Regulation Of Receptor Recycling Membrane Protein Ectodomain Proteolysis Positive Regulation Of Receptor Recycling Neuron Projection Maintenance Regulation Of Amyloid Fibril Formation Brain Morphogenesis Smooth Endoplasmic Reticulum L-glutamate Import Across Plasma Membrane Amyloid-beta Metabolic Process Regulation Of Synaptic Vesicle Cycle Negative Regulation Of DNA Binding Astrocyte Activation Regulation Of Resting Membrane Potential Positive Regulation Of Amino Acid Transport Dorsal/ventral Neural Tube Patterning Positive Regulation Of Glycolytic Process Aspartic-type Endopeptidase Activity Regulation Of Transcription Regulatory Region DNA Binding Amyloid Precursor Protein Metabolic Process Neural Retina Development Anatomical Structure Formation Involved In Morphogenesis Cerebral Cortex Neuron Differentiation Hepatocyte Differentiation
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