ATP6V1G3 and DENND1B

		ATP6V1G3	DENND1B
Description		ATPase H+ transporting V1 subunit G3	DENN domain containing 1B
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Cytosol Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Synaptic Vesicle Membrane	Cytoplasm Cytosol Nuclear Speck Clathrin-coated Vesicle Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Monoatomic Ion Transport Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Endocytosis Protein Transport Endocytic Recycling Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	RAB GEFs exchange GTP for GDP on RABs
Drugs		Tiludronic acid
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cyclophosphamide) ( 23648065) Asthma ( 31959851) Body mass index ( 28552196) General risk tolerance (MTAG) ( 30643258) Mean corpuscular hemoglobin ( 20139978 29403010) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Multiple sclerosis ( 31604244) Red blood cell count ( 29403010)	Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)
Interacting Genes		1 interacting genes: OTX2	7 interacting genes: ARF1 ARF4 ARF5 HOOK1 LNX1 RAB35 RBFOX2
Entrez ID		127124	163486
HPRD ID		16526	13303
Ensembl ID		ENSG00000151418	ENSG00000213047
Uniprot IDs		Q96LB4	Q6P3S1
PDB IDs			3TW8
Enriched GO Terms of Interacting Partners?			GTPase Activity GTP Binding Establishment Of Localization In Cell Vesicle-mediated Transport Protein Transport Intracellular Transport Mitotic Cleavage Furrow Ingression Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Arsenate Reductase (glutaredoxin) Activity Chloride-activated Potassium Channel Activity Intracellular Sodium-activated Potassium Channel Activity Establishment Of Protein Localization Cleavage Furrow Ingression Phospholipase D Activator Activity Glutathione Disulfide Oxidoreductase Activity Cellular Localization
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