TMEM219 and KRABD5

		TMEM219	KRABD5
Description		transmembrane protein 219	KRAB domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Apoptotic Process	Regulation Of DNA-templated Transcription
Pathways		TP53 Regulates Transcription of Death Receptors and Ligands	Generic Transcription Pathway
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Dentures ( 31235808) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Schizophrenia ( 25056061 28991256 29483656) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes			2 interacting genes: APP VAC14
Entrez ID		124446	124411
HPRD ID		18546	14026
Ensembl ID		ENSG00000149932	ENSG00000197302
Uniprot IDs		A0A024R618 Q86XT9	A0A8I5KY90 E9PMU6 Q7Z2F6
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Fusion To Plasma Membrane Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Synaptic Vesicle Membrane Organization Negative Regulation Of Short-term Synaptic Potentiation Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Negative Regulation Of Synaptic Vesicle Recycling Vesicle Fusion Negative Regulation Of SNARE Complex Assembly Postsynaptic Density Membrane Organelle Membrane Fusion Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion Methylation-dependent Protein Binding Modulation Of Chemical Synaptic Transmission Negative Regulation Of Vesicle Fusion Organelle Fusion Regulation Of Synaptic Activity Regulation Of Vesicle-mediated Transport Negative Regulation Of Pinocytosis Membrane Fusion Regulation Of Spontaneous Synaptic Transmission Spontaneous Neurotransmitter Secretion SAGA-type Complex Histone H3K36me3 Reader Activity Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Establishment Of Protein Localization To Chromatin Neuromuscular Process Controlling Posture Presynapse Nuclear Lamina Synaptic Vesicle Docking Regulation Of Synaptic Vesicle Priming Asymmetric Synapse ATAC Complex Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of SNARE Complex Assembly	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor Internalization PAS Complex Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Early Endosome Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Endocytosis Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Presynaptic Endosome Peptidase Activator Activity Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle
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