AGBL1 and SEC11A

		AGBL1	SEC11A
Description		AGBL carboxypeptidase 1	SEC11 homolog A, signal peptidase complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Cytoskeleton	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Tubulin Binding Hydrolase Activity Metal Ion Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis C-terminal Protein Deglutamylation Protein Side Chain Deglutamylation	Signal Peptide Processing Proteolysis Response To Virus
Pathways		Carboxyterminal post-translational modifications of tubulin	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Acute lymphoblastic leukemia ( 33891562) Acute lymphoblastic leukemia (adult) ( 33891562) Anxiety ( 33859377) Bitter alcoholic beverage consumption ( 31046077) Coronary artery calcification ( 23870195) Cytomegalovirus antibody response ( 21993531) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Ischemic stroke ( 26089329) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Migraine ( 21448238) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Neurociticism ( 29500382) Neuroticism ( 29255261) Psychosis (methamphetamine induced) ( 23594818) Response to anti-depressant treatment in major depressive disorder ( 22041458) Rostral middle frontal gyrus volume ( 31530798) Schizophrenia ( 18347602) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212) Triiodothyronine levels ( 30843173) Venous thromboembolism ( 33592630)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)
Interacting Genes			5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6
Entrez ID		123624	23478
HPRD ID		07115	07503
Ensembl ID		ENSG00000273540	ENSG00000140612
Uniprot IDs		A0A1B0GVQ2 Q96MI9	H0YKT4 P67812
PDB IDs			7P2P
Enriched GO Terms of Interacting Partners?		PH Domain Binding Signal Peptide Processing Signal Peptidase Complex Insulin Receptor Substrate Binding
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