PITRM1 and DPT

		PITRM1	DPT
Description		pitrilysin metallopeptidase 1	dermatopontin
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Proteolysis Protein Targeting To Mitochondrion Protein Processing	Cell Adhesion Negative Regulation Of Cell Population Proliferation Collagen Fibril Organization
Pathways		Mitochondrial protein import
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Metabolite levels ( 23823483) Scalp hair shape ( 26926045)	Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Morbidity-free survival ( 17903295) PR interval ( 32439900) Rosacea symptom severity ( 29771307)
Interacting Genes			4 interacting genes: BAG6 DCN LOX TGFB1
Entrez ID		10531	1805
HPRD ID		07142	00510
Ensembl ID		ENSG00000107959	ENSG00000143196
Uniprot IDs		A0A0A0MRX9 A0A7I2V397 Q5JRX3	Q07507
PDB IDs		4L3T 4NGE 4RPU 6XOS 6XOT 6XOU 6XOV 6XOW
Enriched GO Terms of Interacting Partners?		Protein Targeting To Mitochondrion	Glycosaminoglycan Catabolic Process Hyaluronan Catabolic Process Hyaluronan Metabolic Process Muscle Cell Cellular Homeostasis Extracellular Matrix Assembly T Cell Activation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Striated Muscle Tissue Development Regulation Of Muscle Organ Development Glycosaminoglycan Metabolic Process Extracellular Region Collagen Binding Microvillus Regulation Of Developmental Process Extracellular Matrix Negative Regulation Of Endothelial Cell Migration Descending Aorta Development Ascending Aorta Development Connective Tissue Development Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Acetaldehyde Lymphocyte Activation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Leukocyte Activation Positive Regulation Of Monocyte Aggregation Anatomical Structure Morphogenesis Macrophage Migration Inhibitory Factor Receptor Complex Animal Organ Development Golgi Lumen Regulation Of Multicellular Organismal Development Lung Development Positive Regulation Of Primary MiRNA Processing Embryonic Liver Development Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Cell Activation Monocyte Aggregation Peptidyl-lysine Oxidation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Frontal Suture Morphogenesis BAT3 Complex Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Exit From Mitosis Negative Regulation Of Skeletal Muscle Tissue Development Type III Transforming Growth Factor Beta Receptor Binding Langerhans Cell Differentiation Maintenance Of Unfolded Protein Carbohydrate Derivative Catabolic Process Positive Regulation Of ERK1 And ERK2 Cascade
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