GFPT2

Gene Name		glutamine-fructose-6-phosphate transaminase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Glutamine-fructose-6-phosphate Transaminase (isomerizing) Activity Carbohydrate Binding
	Biological Process	Fructose 6-phosphate Metabolic Process UDP-N-acetylglucosamine Biosynthetic Process Energy Reserve Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Glutamine Metabolic Process Carbohydrate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Synthesis of UDP-N-acetyl-glucosamine Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective ALG11 causes ALG11-CDG (CDG-1p) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS		Fat distribution (HIV) ( 21897333) Height ( 20881960)
Protein-protein Interactions		2 interactors: POT1 UBC
Entrez ID		9945
HPRD ID		04842
Ensembl ID		ENSG00000131459
Uniprot IDs		O94808
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Strand Elongation Negative Regulation Of Transferase Activity Telomere Formation Via Telomerase Telomere Capping Positive Regulation Of Helicase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Transferase Activity Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Viral Protein Processing Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Catalytic Activity Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process RNA-dependent DNA Replication Notch Receptor Processing Negative Regulation Of DNA Biosynthetic Process Virion Assembly DNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Telomere Maintenance Via Telomere Lengthening Cellular Polysaccharide Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of DNA Biosynthetic Process Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of DNA Replication Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Catalytic Activity Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		47d 578t allosteric becoming bt dataset distinguish emphasizes epigenetic geo gls1 glutamate glutamine h3k9ac h4k16ac h4k20me3 hdac9 join ldha mb mda mesenchymal metabolically metabolomics modifying myst2 nci suv420h2 trimethylation