FIG4

Description		FIG4 phosphoinositide 5-phosphatase
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GO Annotations	Cellular Component	Golgi Membrane Endosome Lipid Droplet Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Bisphosphate Phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Vacuole Organization Locomotory Behavior Positive Regulation Of Neuron Projection Development Negative Regulation Of Myelination Myelin Assembly Phosphatidylinositol-3-phosphate Biosynthetic Process Myelination Pigmentation Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Neuron Development
Pathways		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Apolipoprotein B levels ( 32203549) Chronotype ( 30696823) Depression in smokers ( 30219690) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Iron status biomarkers (iron levels) ( 28334935) Red cell distribution width ( 32888494)
Interacting Genes		2 interacting genes: APP GORASP2
Entrez ID		9896
HPRD ID		11073
Ensembl ID		ENSG00000112367
Uniprot IDs		Q92562
PDB IDs		7K1W
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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