TRIM66

Description		tripartite motif containing 66
Image
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	Zinc Ion Binding Metal Ion Binding
	Biological Process
Pathways
Drugs
Diseases
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 29273807 28892062 25673413 26426971 26961502 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Fruit consumption ( 32066663) Menarche (age at onset) ( 27182965 21102462 25231870) Waist circumference ( 25673412) Waist-hip ratio ( 25673412)
Interacting Genes		1 interacting genes: DYRK1A
Entrez ID		9866
HPRD ID		19700
Ensembl ID		ENSG00000166436
Uniprot IDs		A0A8Z5E822 A0A994J572 A0A994J7V7 O15016
PDB IDs		6IET 6IEU 8JZW
Enriched GO Terms of Interacting Partners?		Histone H3T45 Kinase Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Neurofilament Splicing Factor Binding Regulation Of Heterochromatin Formation Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Tau-protein Kinase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Chromatin Organization Regulation Of Inclusion Body Assembly Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of RNA Splicing Positive Regulation Of RNA Splicing Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Amyloid-beta Formation Negative Regulation Of Microtubule Polymerization Or Depolymerization Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Signal Transduction By P53 Class Mediator Tau Protein Binding Regulation Of Amyloid Precursor Protein Catabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Microtubule Polymerization Tubulin Binding Cytoskeletal Protein Binding Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Amide Metabolic Process Actin Filament Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Protein Autophosphorylation Double-strand Break Repair Via Homologous Recombination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein-containing Complex Assembly Protein Tyrosine Kinase Activity Circadian Rhythm Recombinational Repair Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of RNA Splicing Double-strand Break Repair DNA Recombination Rhythmic Process Regulation Of Microtubule-based Process
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