ARHGEF10

Description		Rho guanine nucleotide exchange factor 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinesin Binding
	Biological Process	Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Positive Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Centrosome Duplication Positive Regulation Of Stress Fiber Assembly Mitotic Spindle Assembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Cleft lip with or without cleft palate x maternal periconceptional alcohol use interaction (parent of origin effect) ( 31372216) Delta-6 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) End-stage renal disease ( 29885931) HOMA-B (corrected for HOMA-IR) ( 30369944) Multiple sclerosis ( 23412934) Optic disc size ( 31809533) Toenail selenium levels ( 25343990)
Novel Interacting Genes		1 novel interacting genes: PINX1
Interacting Genes		5 interacting genes: CDC42 FHL3 RAC1 RHOA TIAM1
Entrez ID		9639
HPRD ID		09735
Ensembl ID		ENSG00000104728
Uniprot IDs		O15013
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Membrane Invagination Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Wnt Signaling Pathway Small GTPase-mediated Signal Transduction G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Actin Cytoskeleton Organization Regulation Of Stress Fiber Assembly Cell-matrix Adhesion Actin Filament-based Process Thioesterase Binding Focal Adhesion Cell-substrate Adhesion Positive Regulation Of Cell Migration Establishment Or Maintenance Of Cell Polarity Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Motility Cell-cell Junction Organization Positive Regulation Of Locomotion GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Positive Regulation Of Cytoskeleton Organization Regulation Of Neuron Differentiation Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Plasma Membrane Bounded Cell Projection Organization Rac Protein Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Polarity Cerebral Cortex Cell Migration Phagocytosis, Engulfment Postsynapse Positive Regulation Of Lamellipodium Organization Actin Filament Organization Regulation Of Actin Filament Organization Regulation Of Lamellipodium Assembly Telencephalon Cell Migration Intracellular Signaling Cassette Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Regulation Of Synapse Organization
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