ADAMTS2

Description		ADAM metallopeptidase with thrombospondin type 1 motif 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Proteolysis Spermatogenesis Protein Processing Extracellular Matrix Organization Collagen Fibril Organization Lung Development Collagen Catabolic Process Skin Development
Pathways		Collagen biosynthesis and modifying enzymes Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Attention deficit hyperactivity disorder (time to onset) ( 18937294) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Central corneal thickness ( 29760442) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Height ( 25282103) Intake of total sugars ( 31005972) Intraocular pressure ( 29617998 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Liver enzyme levels (alkaline phosphatase) ( 33972514) Refractive astigmatism ( 30306274) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Stroke (pediatric) ( 22990015) Visceral adipose tissue adjusted for BMI ( 22589738) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		1 interacting genes: PIK3R1
Entrez ID		9509
HPRD ID		05173
Ensembl ID		ENSG00000087116
Uniprot IDs		O95450
PDB IDs
Enriched GO Terms of Interacting Partners?		Kinase Regulator Activity Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Activator Activity Phosphatidylinositol 3-kinase Complex, Class IA Insulin Binding Perinuclear Endoplasmic Reticulum Membrane 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol Kinase Activity Positive Regulation Of Focal Adhesion Disassembly Neurotrophin TRKA Receptor Binding Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Phosphatidylinositol 3-kinase Regulator Activity T Follicular Helper Cell Differentiation ErbB-3 Class Receptor Binding Kinase Activator Activity Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Interleukin-18-mediated Signaling Pathway Enzyme-substrate Adaptor Activity Insulin-like Growth Factor Receptor Binding Phosphatidylinositol 3-kinase Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors T-helper Cell Differentiation Regulation Of Toll-like Receptor 4 Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Insulin Receptor Binding Growth Hormone Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Phosphotyrosine Residue Binding Positive Regulation Of Lamellipodium Assembly Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell-matrix Adhesion Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Regulation Of Lamellipodium Assembly Positive Regulation Of D-glucose Transmembrane Transport Osteoclast Differentiation Substrate Adhesion-dependent Cell Spreading T Cell Differentiation Involved In Immune Response Positive Regulation Of RNA Splicing Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Filopodium Assembly Positive Regulation Of Lamellipodium Organization Natural Killer Cell Mediated Immunity Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Filopodium Assembly Cis-Golgi Network
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