ABCG2

Description		ATP binding cassette subfamily G member 2 (JR blood group)
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Mitochondrial Membrane Membrane Raft External Side Of Apical Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Urate Transmembrane Transporter Activity Biotin Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity Riboflavin Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Xenobiotic Transmembrane Transporter Activity Sphingolipid Transporter Activity Protein Dimerization Activity ABC-type Transporter Activity
	Biological Process	Lipid Transport Organic Anion Transport Urate Transport Biotin Transport Sphingolipid Biosynthetic Process Riboflavin Transport Urate Metabolic Process Transmembrane Transport Transepithelial Transport Renal Urate Salt Excretion Export Across Plasma Membrane Transport Across Blood-brain Barrier Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier
Pathways		Sphingolipid de novo biosynthesis Heme biosynthesis Heme degradation Abacavir transmembrane transport Iron uptake and transport Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Paracetamol ADME Ciprofloxacin ADME NFE2L2 regulating MDR associated enzymes
Drugs		Biricodar Avatrombopag Azvudine
Diseases
GWAS		Adult body size ( 32376654) Bitter beverage consumption ( 31046077) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Cardiovascular disease risk factors ( 21943158) Coffee consumption ( 31046077 31959922) Coffee consumption (cups per day) ( 31837886 25288136) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23064961) Glomerular filtration rate ( 29403010) Gout ( 32238385 25646370 23263486 31578528 33832965 21983786 30899057 27899376 29453348) Gout (combined type) ( 32238385) Gout (normal type) ( 32238385) Gout in chronic kidney disease ( 30181573) Gout vs asymptomatic hyperuricemia ( 33832965) Gout vs. Hyperuricemia ( 31289104 29453348) Hyperuricemia ( 29124443 28776340 29453348) Kidney stones ( 31729369) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Renal function-related traits (urate) ( 22797727) Renal overload gout ( 27899376 32238385) Renal underexcretion gout ( 27899376 32238385) Response to allopurinol in gout (change in serum uric acid levels) ( 30924126) Response to statins (LDL cholesterol change) ( 22331829) Serum metabolite levels ( 33031748) Serum urate levels ( 31784582) Serum urate levels in chronic kidney disease ( 30181573) Serum uric acid levels ( 24513273 29403010 21983786 32514006 30305239 26902266 30993211 29124443 31207883) Serum uric acid levels in response to allopurinol in gout ( 25676789) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Urate levels ( 31985003 20139978 23263486 31578528 18834626 20884846) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 29558500 22229870 19503597)
Interacting Genes		1 interacting genes: RNF126
Entrez ID		9429
HPRD ID		04783
Ensembl ID		ENSG00000118777
Uniprot IDs		Q9UNQ0
PDB IDs		5NJ3 5NJG 6ETI 6FEQ 6FFC 6HBU 6HCO 6HIJ 6HZM 6VXF 6VXH 6VXI 6VXJ 7NEQ 7NEZ 7NFD 7OJ8 7OJH 7OJI 8BHT 8BI0 8P7W 8P8A 8P8J 8PXO 8PY4 8Q7B 8QCM 8U2C
Enriched GO Terms of Interacting Partners?		Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination DNA Strand Resection Involved In Replication Fork Processing Epidermal Growth Factor Receptor Binding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Negative Regulation Of ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Monoubiquitination Positive Regulation Of DNA Recombination Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein K63-linked Ubiquitination Regulation Of ERBB Signaling Pathway Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Retrograde Transport, Endosome To Golgi Protein K48-linked Ubiquitination Regulation Of DNA Recombination Cytosolic Transport Recombinational Repair Positive Regulation Of DNA Repair Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
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