LIPG

Description		lipase G, endothelial type
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Golgi Apparatus Cell Surface
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Triacylglycerol Lipase Activity Heparin Binding Phospholipase A1 Activity Lipase Activity Hydrolase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Biosynthetic Process Response To Nutrient Phospholipid Catabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Lipid Catabolic Process Triglyceride Catabolic Process Positive Regulation Of Cholesterol Transport High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis Reverse Cholesterol Transport Regulation Of Lipoprotein Metabolic Process Phospholipid Homeostasis
Pathways		HDL remodeling
Drugs
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Apolipoprotein A1 levels ( 32203549 29084231) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol ester levels in very large HDL ( 29084231) Cholesterol, total ( 19060911 25961943 20686565 24097068) Coronary artery disease ( 29212778) Free cholesterol levels in medium HDL ( 29084231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 18193043 18193044 28270201 30275531 31170924 20864672 26582766 20031538 20686565 19060911 19060906 24097068 24507774 25961943) HDL cholesterol levels ( 28334899 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 31217584 29403010 33339817) Large HDL particle concentration ( 29084231) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 19936222 22286219) Low density lipoprotein cholesterol levels ( 32154731) Mean diameter of HDL particles ( 29084231) Mean spheric corpuscular volume ( 32888494) Medium HDL particle concentration ( 29084231) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors in depression ( 27622933) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Testicular germ cell tumor ( 23666239) Total cholesterol levels ( 33339817 30275531 29403010 28334899) Total cholesterol levels in HDL ( 29084231) Total cholesterol levels in large HDL ( 29084231)
Novel Interacting Genes		1 novel interacting genes: TCF4
Interacting Genes		2 interacting genes: EXOSC5 FANCA
Entrez ID		9388
HPRD ID		04730
Ensembl ID		ENSG00000101670
Uniprot IDs		B4DTR8 Q9Y5X9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of CD40 Signaling Pathway Regulation Of Germ Cell Proliferation Fanconi Anaemia Nuclear Complex TFIIB-class Transcription Factor Binding Beta-catenin-TCF Complex Beta-catenin-TCF7L2 Complex Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Exoribonuclease Complex Nuclear Exosome (RNase Complex) RNA Exonuclease Activity Sno(s)RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) SnRNA 3'-end Processing Female Gonad Development DNA Modification DNA Metabolic Process 3'-5'-RNA Exonuclease Activity SnRNA Processing Nuclear RNA Surveillance Regulation Of Regulatory T Cell Differentiation RNA Surveillance Interstrand Cross-link Repair Male Meiotic Nuclear Division SnRNA Metabolic Process
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