TBCK

Description		TBC1 domain containing kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Spindle Cytoskeleton Midbody Mitotic Spindle
	Molecular Function	Protein Kinase Activity GTPase Activator Activity Protein Binding ATP Binding
	Biological Process	Protein Phosphorylation Cell Population Proliferation Actin Cytoskeleton Organization Regulation Of TOR Signaling
Pathways
Drugs
Diseases
GWAS		Asthma ( 31959851) Diastolic blood pressure ( 27841878) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28739976)
Interacting Genes		1 interacting genes: APP
Entrez ID		93627
HPRD ID		17514
Ensembl ID		ENSG00000145348
Uniprot IDs		Q5HYF5 Q8TEA7
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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