MAP3K6

Name	mitogen-activated protein kinase kinase kinase 6
Structure	No pdb structure
Interactors	2 interactors: HRAS MAP3K5
GO Annotations	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction JNK Cascade P38MAPK Cascade
Drugs	Fostamatinib
GWAS	No GWAS studies recorded
Entrez ID	9064
HPRD ID	05126
Ensembl ID	ENSG00000142733
Uniprot IDs	O95382
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Cellular Senescence Neuron Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of JNK Cascade Intrinsic Apoptotic Signaling Pathway GTPase Complex MAPK Cascade Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Phospholipase C Activator Activity Apoptotic Signaling Pathway Protein Kinase Complex IRE1-TRAF2-ASK1 Complex Positive Regulation Of MAPK Cascade Oncogene-induced Cell Senescence JUN Kinase Kinase Kinase Activity T-helper 1 Type Immune Response Endothelial Cell Apoptotic Process Cell Death Positive Regulation Of Cell Population Proliferation Apoptotic Process Positive Regulation Of Ruffle Assembly Intracellular Signaling Cassette Defense Response To Other Organism Schwann Cell Development Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Targeting To Membrane Regulation Of MAPK Cascade Cellular Response To Gamma Radiation Programmed Cell Death Defense Response To Protozoan Regulation Of Long-term Neuronal Synaptic Plasticity Programmed Necrotic Cell Death Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress MAP Kinase Kinase Kinase Activity Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Cellular Response To Reactive Nitrogen Species Positive Regulation Of P38MAPK Cascade P38MAPK Cascade Regulation Of Receptor Localization To Synapse Regulation Of Protein Targeting To Membrane Response To Protozoan Regulation Of Ruffle Assembly Protein-membrane Adaptor Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Immune Response