MAP3K6

Description		mitogen-activated protein kinase kinase kinase 6
Image		No pdb structure
GO Annotations	Cellular Component
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction JNK Cascade P38MAPK Cascade
Pathways
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		2 interacting genes: HRAS MAP3K5
Entrez ID		9064
HPRD ID		05126
Ensembl ID		ENSG00000142733
Uniprot IDs		O95382
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Senescence Neuron Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of JNK Cascade Intrinsic Apoptotic Signaling Pathway GTPase Complex MAPK Cascade Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Phospholipase C Activator Activity Apoptotic Signaling Pathway Protein Kinase Complex IRE1-TRAF2-ASK1 Complex Positive Regulation Of MAPK Cascade Oncogene-induced Cell Senescence JUN Kinase Kinase Kinase Activity T-helper 1 Type Immune Response Endothelial Cell Apoptotic Process Cell Death Positive Regulation Of Cell Population Proliferation Apoptotic Process Positive Regulation Of Ruffle Assembly Intracellular Signaling Cassette Defense Response To Other Organism Schwann Cell Development Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Targeting To Membrane Regulation Of MAPK Cascade Cellular Response To Gamma Radiation Programmed Cell Death Defense Response To Protozoan Regulation Of Long-term Neuronal Synaptic Plasticity Programmed Necrotic Cell Death Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress MAP Kinase Kinase Kinase Activity Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Cellular Response To Reactive Nitrogen Species Positive Regulation Of P38MAPK Cascade P38MAPK Cascade Regulation Of Receptor Localization To Synapse Regulation Of Protein Targeting To Membrane Response To Protozoan Regulation Of Ruffle Assembly Protein-membrane Adaptor Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Immune Response
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