KBTBD6

Description		kelch repeat and BTB domain containing 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Response To Unfolded Protein Negative Regulation Of Signal Transduction Protein Ubiquitination Regulation Of Rac Protein Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		3 interacting genes: DRD2 GABARAPL2 MAP1LC3C
Entrez ID		89890
HPRD ID		13758
Ensembl ID		ENSG00000165572
Uniprot IDs		Q86V97
PDB IDs		4XC2
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagy Mitophagy Autophagosome Membrane Autophagosome Maturation Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Vacuole Organization Cellular Response To Starvation Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway Response To Starvation Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Cellular Response To Nutrient Levels Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Branching Morphogenesis Of A Nerve Positive Regulation Of Neurotransmitter Uptake Regulation Of Locomotion Involved In Locomotory Behavior Ubiquitin Protein Ligase Binding Intracellular Protein Localization Regulation Of Synapse Structural Plasticity Regulation Of Renal Sodium Excretion Interneuron Migration From The Subpallium To The Cortex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Catabolic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Adenohypophysis Development Neuron-neuron Synaptic Transmission
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