FGD3

Gene Name		FYVE, RhoGEF and PH domain containing 3
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Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of Cdc42 GTPase Activity Positive Regulation Of GTPase Activity Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: CDC42
Entrez ID		89846
HPRD ID		10957
Ensembl ID		ENSG00000127084
Uniprot IDs		F8W7P2 Q5JSP0
PDB IDs		2COC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Hair Follicle Cell Proliferation Actin Filament Branching Submandibular Salivary Gland Formation Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Establishment Of Golgi Localization Positive Regulation Of Metalloenzyme Activity Neuron Fate Determination Epithelial-mesenchymal Cell Signaling Regulation Of Protein Heterodimerization Activity Keratinocyte Development Regulation Of Synapse Structural Plasticity Positive Regulation Of Pseudopodium Assembly Nuclear Migration Cardiac Conduction System Development Golgi Localization Filopodium Assembly Hair Follicle Placode Formation Macrophage Differentiation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Dendritic Cell Migration Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Nucleus Localization Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Hair Follicle Morphogenesis Epithelial Cell-cell Adhesion Substantia Nigra Development Positive Regulation Of Cytokinesis Epidermis Morphogenesis Keratinization Salivary Gland Morphogenesis Nucleus Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Salivary Gland Development Regulation Of Filopodium Assembly Negative Regulation Of ERBB Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Cell Fate Determination Skin Morphogenesis Neural Nucleus Development Organelle Transport Along Microtubule Sprouting Angiogenesis Regulation Of Cytokinesis Regulation Of Lipid Kinase Activity Exocrine System Development Positive Regulation Of Neuron Apoptotic Process Heart Contraction Positive Regulation Of DNA Replication
Tagcloud ?		applicable attractor bcam biomarker bionetworks calculating called cd68 consideration cxcl12 dnajb9 dream existing facility hormonal lym mes metagene metagenes outperform predictions remarkable sage selector suggestion susd3 unexpected universally winning